Clinical trial · Observational
Cryptosporidium Infection and Human Colorectal Cancer
Role of the Protozoa Cryptosporidium in the Development of Colorectal Cancer in Humans
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
It has been reported that Cryptosporidium parvum, a species of a protozoan frequently isolated from humans and animals, is able to induce digestive adenocarcinoma in a rodent model. Consistently, some epidemiological studies have reported an association with cryptosporidiosis in patients with colorectal adenocarcinoma. However, the correlation between cryptosporidiosis and human digestive cancer remains unclear at this time, and it is not known whether this intracellular parasite, considered an opportunistic agent, is able to induce gastrointestinal malignancies in humans. In order to add new arguments for a probable association between cryptosporidiosis and digestive human cancer, the main aim of this study is to determine prevalence and to identify species of Cryptosporidium among a French digestive cancer population.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colonic Neoplasms | Colon Neoplasm | ALIAS | 0.90 |
| Cryptosporidiosis | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Detection of Cryptosporidium infection | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Patients with colon cancer
- description
- Patients with colon cancer of recent diagnosis will be recruited in consultation either in the surgical or gastroenterology departments
- interventionNames
- Diagnostic Test: Detection of Cryptosporidium infection
- label
- Patients without colon cancer
- description
- Patients without colon cancer but with other gastrointestinal pathology needing a biopsy or a surgical procedure will be recruited either in the surgical or gastroenterology departments
- interventionNames
- Diagnostic Test: Detection of Cryptosporidium infection
Primary outcomes (1)
- measure
- Prevalence of Cryptosporidium
- timeFrame
- 3 years
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: Cases: * Age ≥ 18 years old * Patients with colonic adenocarcinoma/intraepithelial neoplasia diagnosed prior to chemotherapy or radiotherapy who will undergo scheduled surgery. Patients with rectal cancer with indication for neoadjuvant treatment will still be included, but only biopsies used for diagnosis will be used * Patient capable of receiving informed information * Written informed consent * Affiliation to a social security scheme Controls: * Age ≥ 18 years old * Patients with endoscopic indication for benign pathology * Patients with indication for colectomy for benign pathology * Patients with digestive cancer (stomach, oesophagus, biliary, pancreatic, etc.) of any type other than colorectal cancer before chemotherapy or radiotherapy * Patient capable of receiving informed information * Written informed consent * Affiliation to a social security scheme Exclusion Criteria: * Patients undergoing pre-operative chemotherapy. * Patients who have already had chemotherapy for less than one year or other immunosuppressive treatment
References
Publications (0)
Data not yet available