Clinical trial · Observational
SHOX2_PTGER4 DNA Methlyation in Lung Cancer
Establishing a Non-invasive Diagnostic Biomarker Test for Early Diagnosis of Lung Cancer
NCT04321499CI-TRIAL-00044219Epi1completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Data on SHOX2 and PTGER4 DNA Methylation suggest possible use as a biomarker for early lung cancer diagnosis. In this study a control group consisting of COPD patients with a CT-scan of the chest no older than 6 weeks and a control group of patients with a nodule and ruled out diagnosis of lung cancer will be included. SHOX2 and PTGER4 will be analyzed via PCR.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lungcancer | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| lung cancer | Genetic | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- lung cancer
- description
- stage IA-IIIA lung cancer
- interventionNames
- Genetic: lung cancer
- label
- benign nodules
- description
- ruled out lung cancer via Operation or CT-scan follow-up
- interventionNames
- Genetic: lung cancer
Primary outcomes (1)
- measure
- DNA Methylation at early stages of lung cancer
- timeFrame
- 1 year
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 95 Years
Show eligibility criteria text
Inclusion Criteria: suspicious finding for lung cancer on CT-scan Exclusion Criteria: * history significant for former malignant diseases
References
Publications (1)
- BACKGROUNDWeiss G, Schlegel A, Kottwitz D, Konig T, Tetzner R. Validation of the SHOX2/PTGER4 DNA Methylation Marker Panel for Plasma-Based Discrimination between Patients with Malignant and Nonmalignant Lung Disease. J Thorac Oncol. 2017 Jan;12(1):77-84. doi: 10.1016/j.jtho.2016.08.123. Epub 2016 Aug 18. PMID 27544059