Clinical trial · Interventional
Dosage of Epidural Morphine in Elderly Patients
Epidural Morphine for Geriatrics Undergoing Lower Abdominal Cancer Surgery: a Dose Response Study
NCT04316871CI-TRIAL-00086794completedPhase 4Results postedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This a clinical trial that evaluates the efficacy and safety of three different doses of morphine, namely 1.5 mg, 3 mg and 4.5 mg, via the epidural route regarding reducing pain in elderly patients after a cancer surgery in the lower abdomen
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Abdominal Cancer | Malignant Abdominal Neoplasm | ALIAS | 0.90 |
| Age Problem | — | UNRESOLVED | — |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| 1.5 mg of Morphine Sulfate | Drug | — | UNRESOLVED |
| 3 mg of Morphine Sulfate | Drug | — | UNRESOLVED |
| 4.5 mg of Morphine Sulfate | Drug | — | UNRESOLVED |
| Normal saline | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- type
- PLACEBO_COMPARATOR
- label
- Group D
- description
- A total volume of 10 mL injection 5 mL of bupivacaine hydrochloride 0.125% diluted in 5 mL preservative-free normal saline by the hospital pharmacist.
- interventionNames
- Drug: Normal saline
- type
- ACTIVE_COMPARATOR
- label
- Group A
- description
- A total volume of 10 mL injection: 5 mL of bupivacaine hydrochloride 0.125% with 1.5 mg of preservative-free morphine diluted in 5 mL preservative-free normal saline by the hospital pharmacist.
- interventionNames
- Drug: 1.5 mg of Morphine Sulfate
- type
- ACTIVE_COMPARATOR
- label
- Group B
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 60 Years
- Maximum age
- 100 Years
Show eligibility criteria text
Inclusion Criteria: 1\. Men and women aged ≥ 60 years, who are planned to undergo lower abdominal cancer surgery. 2- ASA I and II classifications. 2. Surgeries via infra-umbilical abdominal incision is considered eligible. Exclusion Criteria: 1. Patient refusal. 2. Patients who are morbidly obese (body mass index ≥ 40 kg/m2). 3. Those with contraindications to neuraxial analgesia. 4- psychiatric illness that would interfere with the perception and the assessment of pain.
References
Publications (2)
- BACKGROUNDMcKeown JL. Pain Management Issues for the Geriatric Surgical Patient. Anesthesiol Clin. 2015 Sep;33(3):563-76. doi: 10.1016/j.anclin.2015.05.010. Epub 2015 Jul 3. PMID 26315638
- BACKGROUNDPalmer CM, Nogami WM, Van Maren G, Alves DM. Postcesarean epidural morphine: a dose-response study. Anesth Analg. 2000 Apr;90(4):887-91. doi: 10.1097/00000539-200004000-00021. PMID 10735794