Clinical trial · Interventional
Comparison of Hypertonic Saline and Mannitol on Brain Relaxation During Supratentorial Tumors Resection
Comparison of Continuous Infusion of 3% Hypertonic Saline, Bolus of 3% Hypertonic Saline and Mannitol on Brain Relaxation During Supratentorial Tumor Resection: A Prospective, Randomized, Clinical Study
NCT04314674CI-TRIAL-00044130unknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Hyperosmotic agents are used to decrease intracranial pressure. The aim of the study is to compare the effects of continuous 3% hypertonic saline (HS), bolus HS and 20% mannitol on intraoperative brain relaxation in patients with raised intracranial pressure during surgery for supratentorial tumors.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Brain Tumor, Adult: Glioblastoma | Brain Neoplasm | ALIAS | 0.85 |
| Brain Tumor - Metastatic | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| 20% mannitol | Drug | — | UNRESOLVED |
| %3 HS bolus | Drug | — | UNRESOLVED |
| %3 HS infusion 20 ml/h | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- ACTIVE_COMPARATOR
- label
- %3 HS bolus 3 mL.kg-1
- description
- After the head fixation 3 mL.kg-1 %3 hypertonic saline will be administered over the 20 min intravenously.
- interventionNames
- Drug: %3 HS bolus
- type
- ACTIVE_COMPARATOR
- label
- %3 HS infusion 20 ml/h
- description
- After the head fixation 3% hypertonic saline at 20 ml/h infusion rate will be administered during the operation
- interventionNames
- Drug: %3 HS infusion 20 ml/h
- type
- ACTIVE_COMPARATOR
- label
- %20 mannitol 0,6 gr.kg-1
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: * Elective supratentorial tumor resection * Glioblastoma multiforme * Metastatic tumor * Intracranial shift \>0.5 cm * GCS\>13 Exclusion Criteria: * Renal failure * Heart failure * Electrolyte imbalance
References
Publications (3)
- BACKGROUNDQuentin C, Charbonneau S, Moumdjian R, Lallo A, Bouthilier A, Fournier-Gosselin MP, Bojanowski M, Ruel M, Sylvestre MP, Girard F. A comparison of two doses of mannitol on brain relaxation during supratentorial brain tumor craniotomy: a randomized trial. Anesth Analg. 2013 Apr;116(4):862-8. doi: 10.1213/ANE.0b013e318282dc70. Epub 2013 Jan 25. PMID 23354336
- BACKGROUNDDostal P, Dostalova V, Schreiberova J, Tyll T, Habalova J, Cerny V, Rehak S, Cesak T. A comparison of equivolume, equiosmolar solutions of hypertonic saline and mannitol for brain relaxation in patients undergoing elective intracranial tumor surgery: a randomized clinical trial. J Neurosurg Anesthesiol. 2015 Jan;27(1):51-6. doi: 10.1097/ANA.0000000000000091. PMID 25036870
- BACKGROUNDHernandez-Palazon J, Fuentes-Garcia D, Domenech-Asensi P, Piqueras-Perez C, Falcon-Arana L, Burguillos-Lopez S. A comparison of equivolume, equiosmolar solutions of hypertonic saline and mannitol for brain relaxation during elective supratentorial craniotomy. Br J Neurosurg. 2016;30(1):70-5. doi: 10.3109/02688697.2015.1109061. Epub 2015 Nov 16. PMID 26571037