Metabolomics Explores Biomarkers for Metastatic Breast Cancer

Inclusion Criteria:

* Age: 18-70 yrs.
* Any menopausal status.
* Any hormone receptor status.
* Patients must have histologically or imaging confirmed breast cancer with visceral metastatic.
* Patients must have measurable disease, per RECIST criteria v1.1.21.
* Estimated life expectancy of ≥ 12 weeks.
* Ability to swallow oral medications.
* Participants must have adequate organ function as defined by:

  1. ANC ≥1.5 x 109/L, platelet count ≥100 x 109/L, haemoglobin ≥ 10 g/dL.
  2. creatinine \< 1.5 x UNL (upper normal limit).
  3. Total bilirubin \< 1.5x UNL.
  4. ALT \& AST \< 2.5xUNL; alkaline phosphatase \< 2.5xUNL.
  5. Creatine phosphokinase (CPK) ≤ 2.5 x UNL.
* Patients with CNS metastatic disease are allowed if the disease is controlled and stable for at least 3 months by CT or MRI.

Exclusion Criteria:

* Current severe, uncontrolled systemic disease (e.g. pulmonary, or metabolic disease; wound healing disorders; ulcers; or bone fractures).
* History of other malignancies.
* No measureable lesion is present, as defined by RECIST 1.1.
* Patients who suffer from a medical or psychiatric condition that, in the opinion of the principal investigator, would impair their ability to participate in the study.
* Concurrent interventional studies.