Clinical trial · Interventional
Micro-Ultrasound for the Detection and Localization of Prostate Cancer Tumors in Patients Undergoing Radical Prostatectomy
Micro-Ultrasound to Whole Mount Image Correlation for Detection and Localization of Prostate Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This trial studies the ability of micro-ultrasound to detect and characterize prostate cancer tumors in patients undergoing radical prostatectomy (removal of the entire prostate and some of the tissue around it). Usually multiparametric magnetic resonance imaging is used for the detection and targeted therapy of prostate cancer, but its accuracy remains imperfect. Micro-ultrasound may be superior as it provides real-time tumor visualization which may simplify and improve prostate cancer targeted therapy. This may also reduce the need for and substantial costs of radical prostatectomy.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Prostate Carcinoma | Prostate Carcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Digital Image Analysis | Device | — | UNRESOLVED |
| Radical Prostatectomy | Procedure | — | UNRESOLVED |
| Transrectal Ultrasound | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Diagnostic (TRUS)
- description
- Patients may undergo TRUS prior to standard-of-care radical prostatectomy. Following radical prostatectomy, removed glands are scanned and micro-US, standard of care mpMRI, and whole mount images are analyzed and compared.
- interventionNames
- Device: Digital Image Analysis
- Procedure: Radical Prostatectomy
- Procedure: Transrectal Ultrasound
Primary outcomes (1)
- measure
- Identification of prostate cancer foci
- timeFrame
- Up to 3 years
- description
- Will be evaluated by comparing sensitivity and positive predictive value of multiparametric magnetic resonance imaging (mpMRI) and micro-ultrasound (US) for identification of prostate cancer (CaP) foci. Measurement tool = chi squared test
Secondary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- Male
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Standard-of-care mpMRI within the past 12 months * Biopsy-proven prostate cancer, Gleason grade \>= 3+3 * Maximum posterior-to-anterior prostate dimension of =\< 6 cm * Scheduled to receive standard-of-care radical prostatectomy Exclusion Criteria: * Maximum posterior-to-anterior prostate dimension greater than 6 cm * Prior radiation or focal treatment for prostate cancer * Inability to have a transrectal ultrasound scan * Prostate biopsy \< 4 weeks prior to surgery
References
Publications (0)
Data not yet available