Percutaneous Lung Biopsy Using Cone Beam CT With Virtual Guidance: a Randomized Control Trial

Image-guided percutaneous lung biopsy is an essential procedure in lung cancer management, where it is integral to confirming the diagnosis and determining tumour histology. An ideal percutaneous lung biopsy also needs to have a short procedure time with accurate needle placement to minimize the inherent risk of the procedure. Since the 1970s, conventional Multi-detector CT (MDCT) has been the modality of choice in percutaneous lung biopsy. Recent research has proposed CT fluoroscopy and cone-beam CT (CBCT) as alternative methods. Virtual guidance has been developed to improve target visibility and access for these complex cases. More specifically, it plans a potential computed 3D needle path before the procedure, using the CBCT images. This 3D path can be transposed onto real time fluoroscopic images to guide the biopsy, thus potentially improves patients' safety due to more accurate needle placement.

Sex

All

Minimum age

18 Years

Inclusion Criteria:

* Solitary or multiple lung lesions (solid or subsolid nodule, pulmonary infiltrate) ≥1cm

Exclusion Criteria:

* Patient \<18 years old
* Patient not able to give informed consent
* Uncooperative patient who is unable to hold still or hold their breath for safe biopsy
* Lesions \<1cm
* Lesions within 1cm of vital thoracic structures such as the great vessels and the mediastinum
* Peripheral lesions accessible to biopsy with ultrasound guidance