Study to Assess the Safety and Tolerability of Repeated Doses of an Investigational New Drug in Patients With Cancer and Cachexia.

Inclusion Criteria:

* Documented histologic or cytologic diagnosis of advanced metastatic NSCLC, advanced/unresectable pancreatic cancer, or metastatic colorectal cancer.
* Cachexia, defined by BMI \<20 kg/m2 with involuntary weight loss of \>2% within 6 months prior to screening or Involuntary weight loss of \>5% within 6 months prior to screening irrespective of BMI or If medical record documentation is unavailable, patient's report will suffice to estimate involuntary body weight loss.;
* Will receive the following for non-small cell lung cancer:

  * a platinum + pemetrexed ± pembrolizumab or
  * a platinum + nab paclitaxel or paclitaxel ± pembrolizumab or
  * pembrolizumab alone
* Will receive the following for pancreatic cancer:

  * FOLFIRINOX or
  * Nab-Paclitaxel + Gemcitabine
  * Gemcitabine
* Will receive the following for colorectal cancer:

  * FOLFOX +/- Biologic (Bevacizumab or Cetuximab/Panitumumab) or
  * FOLFIRI +/- Biologic (Bevacizumab or Cetuximab/Panitumumab) or
  * FOLFOXIRI +/- Biologic (Bevacizumab or Cetuximab/Panitumumab) or
  * Pembrolizumab for MSI-H • Will be entering the study at the first or second cycle of their current course of anti-cancer treatment/ therapy.
* Adequate renal and liver function.
* Signed informed consent.

Exclusion Criteria:

* All other forms of cancers not specified above unless currently considered cured (\>5 years without evidence of recurrence).
* Planned radiation therapy as part of the primary anti-tumor therapy regimen. However, localized radiation therapy for symptomatic relief is permitted
* Cachexia caused by other reasons: Severe COPD requiring use of home O2, heart failure or AIDS.
* known symptomatic brain metastases requiring steroids.
* Active hepatitis B or C virus.
* Confirmed positive HIV test.
* Current active reversible causes of decreased food intake.
* Receiving tube feedings or parenteral nutrition at Screening.
* Elevated blood pressure that cannot be controlled by medications.
* Women who are pregnant or breast-feeding