Clinical trial · Observational
The Mechanism of Sox4 Transcription in Regulation of Angiogenesis in Hepatocellular Carcinoma
SOX4 Activates CXCL12 in Hepatocellular Carcinoma Cells to Modulate Endothelial Cell Migration and Angiogenesis in Vivo
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Two hundred HCC patients with partial hepatectomy were enrolled as a cohort for observational study. The inclusion criterion was intended curative hepatectomy for HCC patients by image analysis, and the exclusion criteria were unresectable disease, synchronous cancers, recurrent cancers, or distant metastasis. The study endpoint was 30 March 2019, and tumor staging was based on the 8th edition of the American Joint Committee on Cancer (AJCC) TNM staging system for HCC
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Translational Research of SOX4 in Hepatocellular Carcinoma | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| microvessel density | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- SOX4 high
- description
- Nuclear expression of SOX4 over 90% in tumor specimen was defined as SOX4 high group
- interventionNames
- Other: microvessel density
- label
- SOX4 low
- description
- Nuclear expression of SOX4 less than 90% in tumor specimen was defined as SOX4 low group
- interventionNames
- Other: microvessel density
Primary outcomes (1)
- measure
- Disease free survival (DFS)
- timeFrame
- a month
- description
- The length of time from curative hepatectomies and recurrence or mortality
Secondary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
- Maximum age
- 85 Years
Show eligibility criteria text
Inclusion Criteria: subjects with pathologic diagnosis of hepatocellular carcinoma and curative partial hepatectomies - Exclusion Criteria: history of different malignant disease, subject cannot be treated with curative surgery -
References
Publications (0)
Data not yet available