Clinical trial · Interventional
Development of a New Immunochemistry Method Using Antibodies of Proteins Related Pancreatic Cancer
Clinical Validation of a New Immunochemistry Method Using Antibody of Methionyl-tRNA synthetase1(MARS1) in the Pancreatic Cancer Cell; Multicenter Prospective Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Identifying the malignancy of pancreatic mass using endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is important for treatment decision-making and prognosis prediction. The sensitivity of EUS-FNA cytology specimens based on Papanicolaou (Pap) staining is low, which hampers accurate diagnosis of pancreatic mass. We assessed the diagnostic value of immunohistochemical (IHC) and immunofluorescence (IF) staining for methionyl-tRNA synthetase 1 (MARS1).
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pancreatic Cancer | Malignant Pancreatic Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Cytology staining | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Pancreatic Cancer
- description
- This arm includes patients with pancreatic cancer. Cytology specimens will be obtained with endoscopic ultrasound-guided fine-needle aspiration in patients with pancreatic cancer. Cytology staining will be performed in the cytology specimens.
- interventionNames
- Diagnostic Test: Cytology staining
Primary outcomes (1)
- measure
- The comparison of sensitivity between conventional staining method and new staining method
- timeFrame
- 1 year
- description
- The sensitivity of new staining method will be compared with the conventional Pap staining of endoscopic ultrasound-guided fine-needle aspiration cytology
Secondary outcomes (1)
- measure
- The evaluation of correlation index of staining at three type slides
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 19 Years
Show eligibility criteria text
Inclusion Criteria: 1. Patients with pancreatic cancer confirmed by imaging (CT, MRI, PET-CT) 2. Patients with pancreatic cancer diagnosed using cytology by endoscopic ultrasound 3. Patients who underwent surgical treatment with pancreatic cancer Exclusion Criteria: 1. Minors under the age of 19, vulnerable subjects such as illiteracy 2. Excludes necrotic specimens 3. Samples with non-diagnostic cytology results and insufficient cells for further evaluation 4. Samples classified as neoplastic (benign or other)
References
Publications (0)
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