Clinical trial · Interventional
Intralesional Vitamin D Injection for Treatment of Common Warts
Efficacy of Intralesional Vitamin D Injection for Treatment of Common Warts: A Randomized Controlled Trial
NCT04278573CI-TRIAL-00076585completedPhase 2Results postedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Researchers are trying to find out if injecting Vitamin D into a wart is an effective treatment.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Warts | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Placebo | Drug | — | UNRESOLVED |
| Vitamin D3 | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Vitamin D3 Treatment Group
- description
- Subjects will receive a Vitamin D3 injection into their wart
- interventionNames
- Drug: Vitamin D3
- type
- PLACEBO_COMPARATOR
- label
- Placebo Group
- description
- Subjects will receive a placebo injection into their wart
- interventionNames
- Drug: Placebo
Primary outcomes (1)
- measure
- Complete Regression of Wart
- timeFrame
- 24 weeks
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Adult patients seen at the Mayo Clinic Rochester practices * Patients suffering from one or more cutaneous warts as diagnosed by the examining physician at baseline visit on typical diagnostic characteristics * Able to provide consent * Both recalcitrant and non-recalcitrant warts will be included Exclusion Criteria: * Patients with prior use of home or office-based destructive treatments for this wart(s) in the last 1 month with salicylic acid (SA) or cryotherapy * Immunoadjuvant therapy for warts in the last 4 months (e.g Candida) * History of vitamin D injection of warts ever * High-dose vitamin D supplementation (\>4,000 IU daily or equivalent) in the preceding 3 months * Pregnancy or lactation * Facial or genital warts * Lesions not felt by the examining clinician to be a wart (e.g., corns or calluses) * Immunosuppression (to include immunosuppressive medications or conditions as judged by the physician evaluating the patient at the baseline visit). * Allergy to sesame oil
References
Publications (1)
- DERIVEDMerry SP, Brennan DN, Duvall MJ, Stanek JB, O'Dowd EK, Thacher TD. Intralesional Injection of Vitamin D3 for Treatment of Cutaneous Warts: A Randomized, Double-Blind, Placebo-Controlled Trial. J Prim Care Community Health. 2025 Jan-Dec;16:21501319251365853. doi: 10.1177/21501319251365853. Epub 2025 Aug 23. PMID 40847834