Clinical trial · Interventional
Magnetic Resonance Imaging for Lung Radiotherapy
Magnetic Resonance Imaging for Lung Radiotherapy a Prospective Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to investigate the use of Magnetic Resonance Imaging (MRI) in the diagnostic and planning phase of radiotherapy for lung cancer and then introduce it into on-treatment imaging to improve the accuracy of radiotherapy. The study compromises of two phases, a technical phase followed by a clinical phase. The aim of the technical phase is to develop and test MR sequences using a diagnostic scanner for use in the chest. This will be carried out on a humanoid phantom and subsequently healthy volunteers. The second phase will be a clinical phase to assess the accuracy of visualising all thoracic structures and the tumour in lung cancer patients using the defined MR sequences. It will compromise of 2 parts; the first part will involve 3 lung cancer patients as a pilot to enable the fine tuning of the sequences. The 2nd part will involve the evaluation of MRI in relation to planning CT in 12 lung cancer patients. The hypothesis is that the use of 4D MRI will be more accurate in defining the tumour and intrathoracic structures thanachieved with the current standard of 4DCT to improve the accuracy and potentially the outcome of radical radiotherapy for non-small cell lung cancer.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| 4D MRI | Diagnostic Test | — | UNRESOLVED |
| MRI scan | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Study participants cohort I
- description
- 3 stage III NSCLC patients receiving radiotherapy will be imaged, each for a single MRI session using TWIST and HASTE sequences.
- interventionNames
- Diagnostic Test: MRI scan
- Diagnostic Test: 4D MRI
- type
- EXPERIMENTAL
- label
- Study participants cohort II
- description
- 12 patients will be imaged, each for two MRI sessions taking place during the radiotherapy schedule and separated by at least a week.
- interventionNames
- Diagnostic Test: MRI scan
- Diagnostic Test: 4D MRI
Primary outcomes (1)
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 85 Years
Show eligibility criteria text
Inclusion Criteria: This study will recruit patients due to have radical external beam radiotherapy as per standard institutional practice. The criteria specified in the institutional protocol are: * Histologically verified NSCLC or presumed not histologically verified but MDT reviewed and agreed if obtaining biopsy is considered too risky * Stage II, IIIA \& IIIB (AJCC, 7th Edition TNM), fully staged with CT, PET-CT +/-EBUS for mediastinal staging * WHO performance status ≤ 2 * Adequate respiratory function * Absence of malignant effusion * Aged 18 and over Exclusion Criteria: * Under 18 years or age * Patients not able to have radical radiotherapy * Pregnant or lactating women * Unable to give informed consent
References
Publications (0)
Data not yet available