A Study of MSB2311 in Advanced Solid Tumors

Inclusion Criteria:

* Voluntary informed consent, knowledge of the study and willingness to follow and has ability to complete all trial procedures
* There is a histologically or cytologically confirmed, locally advanced or metastatic tumor that is not resectable

  * b period participants shall provide the archive paraffin embedding tumor tissue samples
* The eastern United States cooperative tumor group (ECOG) score was 0 or 1
* Expect to survive at least 3 months
* Subjects must have measurable lesions (at least 1 lesion) and minimum tumor-specific antigen levels where applicable
* If you have received antitumor therapy, you need to meet certain conditions
* There are suitable organs and hematopoietic functions
* Male subjects and female subjects of child-bearing age shall agree to take effective, investigator-approved contraceptive measures from the date of signing the informed consent until 3 months after the last administration

Exclusion Criteria:

* The patient has had a malignant tumor other than the tumor treated in this study within 5 years prior to the first administration, unless the medical examiner of the study group and sponsor agrees that the old tumor has been cured or will not metastasise or cause death in this study
* Adverse reactions to previous treatments did not return to CTCAE v4.03 rating ≤ 1, except for residual alopecia effect
* Patients who had been treated with anti-pd-1 or pd-l1 antibodies, or who had been treated with antibodies/drugs that target any other t-cell co-regulatory proteins within 12 weeks of the first administration of the drug in this study
* Patients with primary CNS tumors or CNS metastases known or identified during screening
* Subjects with active or pre-existing autoimmune disease that may recur or patients at high risk
* Patients who had major surgery in the first 4 weeks of screening and who were expected to have major surgery during the study period including a 28-day screening period
* Subjects who require systemic treatment with corticosteroids or other immunosuppressive drugs within 14 days prior to enrollment or during the study period
* Sudden pulmonary disease, interstitial pulmonary disease or pneumonia, or other uncontrolled systemic disease, including diabetes, pulmonary fibrosis, acute pulmonary disease, cardiovascular disease, including hypertension, except local interstitial pneumonia induced by radiotherapy
* A history of human immunodeficiency virus infection, or other acquired or congenital immunodeficiency, or a history of organ transplantation, or stem cell transplantation
* Had a history of tuberculosis, or had tuberculosis disease at the time of screening
* Patients with chronic hepatitis b or active hepatitis c.Hepatitis b carriers, stable hepatitis b after drug treatment and cured hepatitis c patients can be included in the group
* Patients who have been seriously infected within 4 weeks prior to first administration, or who have developed signs or symptoms of any active infection within the previous 2 weeks, or who require antibiotic treatment within the previous 2 weeks;Unexplained fever occurred before the first administration and the body temperature exceeded 38.5℃
* Subjects who have previously been known to have a severe allergic reaction to a macromolecular protein preparation/monoclonal antibody or to any component of the test drug
* Immune-related adverse events (irAE) grade ≥3 occurred after receiving immunotherapy
* Participated in clinical trials of other drugs within 4 weeks before enrollment
* A history of alcohol, drug or substance abuse within the last 1 year
* Has a clear history of neurological or psychiatric disorders, such as epilepsy, dementia, poor compliance
* A woman who is pregnant or breastfeeding