Clinical trial · Interventional
2-day Prophylactic Antibiotic is Effective in Transoral Endoscopic Thyroidectomy
NCT04268407CI-TRIAL-00059998completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
In transoral thyroidectomy via vestibular approach (TOETVA), prophylactic antibiotic for 5\~7 days is recommended for the clean-contaminated wound. In this study, the investigators design a 2-day versus 7-day antibiotic prophylaxis to compare the surgical result and infection rate.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Thyroid Nodule | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Amoxicillin Clavulanate | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- 2-day prophylactic antibiotics
- description
- use prophylactic antibiotic for 2 days after transoral thyroidectomy
- interventionNames
- Drug: Amoxicillin Clavulanate
- type
- OTHER
- label
- 7-day prophylactic antibiotic
- description
- use prophylactic antibiotic for 7 days after transoral thyroidectomy
- interventionNames
- Drug: Amoxicillin Clavulanate
Primary outcomes (1)
- measure
- post-operative infection
- timeFrame
- within one month after operation
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: 1. Suspicious or proved thyroid cancer with size smaller than 4cm 2. Symptomatic benign thyroid nodules less than 6cm in size 3. Thyroid cyst 4. Follicular neoplasm 5. Graves' disease Exclusion Criteria: 1. Previous thyroid or parathyroid surgery 2. History of radiation at neck 3. Could not tolerate the general anesthesia.
References
Publications (3)
- BACKGROUNDAnuwong A, Ketwong K, Jitpratoom P, Sasanakietkul T, Duh QY. Safety and Outcomes of the Transoral Endoscopic Thyroidectomy Vestibular Approach. JAMA Surg. 2018 Jan 1;153(1):21-27. doi: 10.1001/jamasurg.2017.3366. PMID 28877292
- BACKGROUNDFernandez-Ranvier G, Meknat A, Guevara DE, Inabnet WB 3rd. Transoral Endoscopic Thyroidectomy Vestibular Approach. JSLS. 2019 Oct-Dec;23(4):e2019.00036. doi: 10.4293/JSLS.2019.00036. PMID 31719772
- BACKGROUNDWang C, Zhai H, Liu W, Li J, Yang J, Hu Y, Huang J, Yang W, Pan Y, Ding H. Thyroidectomy: a novel endoscopic oral vestibular approach. Surgery. 2014 Jan;155(1):33-8. doi: 10.1016/j.surg.2013.06.010. Epub 2013 Jul 24. PMID 23890962