Clinical trial · Interventional
Arterial Base Fluorescence Segmental Positive Staining
Superselective Intra-arterial Hepatic Injection of Indocyanine Green (ICG) for Fluorescence Image-guided Segmental Positive Staining
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
More and more laparoscopic hepatectomy were performed due to increasing experience, well designed instruments and energy device. But the localization of tumor and resection line design are still relative difficult comparing open approach due to limit space. Intraoperative liver segmentation can be obtained by ultrasound-guide intraportal injection of a fluorophore and illuminating with a Near-Infrared light source for positive staining and by intravenous injection after ligation of segmental vessels for negative staining .The ultrasound guide intraportal injection approach is challenging in the minimally-invasive setting. However hepatocelluar carcinoma(HCC) was supplied by hepatic artery mainly. The investigators aimed to evaluate the feasibility of arterial base positive staining for fluorescence liver segmentation in human by superselective intra-hepatic artery injection of Indocyanine Green (ICG) .
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hepatic Carcinoma | Hepatocellular Carcinoma | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Superselective Intra-arterial Hepatic Injection of Indocyanine Green (ICG) for Fluorescence Image-guided Segmental Positive Staining | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- super-selective hepatic artery ICG injection group
- description
- single arm for feasibility study of intra-hepatic artery base fluorescent segmental demarcation
- interventionNames
- Procedure: Superselective Intra-arterial Hepatic Injection of Indocyanine Green (ICG) for Fluorescence Image-guided Segmental Positive Staining
Primary outcomes (5)
- measure
- Fluorescent hepatic segment demarcation area
- timeFrame
- intra-operative period
- description
- The surface size of fluorescent enhanced hepatic segment were measured as cm x cm .
- measure
- the rate of fluorescent demarcation corresponding to US guide resection area
- timeFrame
- intra-operative period
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
- Maximum age
- 85 Years
Show eligibility criteria text
Inclusion Criteria: * Single Hepatocellular carcinoma. * plan of Laparoscopic hepatectomy. * Age between 20 to 85 y/o. Exclusion Criteria: * allergies to iodine or ICG * Liver cirrhosis * coagulopathy * chronic kidney disease * pregnancy
References
Publications (12)
- BACKGROUNDDiana M, Liu YY, Pop R, Kong SH, Legner A, Beaujeux R, Pessaux P, Soler L, Mutter D, Dallemagne B, Marescaux J. Superselective intra-arterial hepatic injection of indocyanine green (ICG) for fluorescence image-guided segmental positive staining: experimental proof of the concept. Surg Endosc. 2017 Mar;31(3):1451-1460. doi: 10.1007/s00464-016-5136-y. Epub 2016 Aug 5. PMID 27495341
- RESULTIshizawa T, Gumbs AA, Kokudo N, Gayet B. Laparoscopic segmentectomy of the liver: from segment I to VIII. Ann Surg. 2012 Dec;256(6):959-64. doi: 10.1097/SLA.0b013e31825ffed3. PMID 22968066
- RESULTFerrero A, Lo Tesoriere R, Russolillo N, Vigano L, Forchino F, Capussotti L. Ultrasound-guided laparoscopic liver resections. Surg Endosc. 2015 Apr;29(4):1002-5. doi: 10.1007/s00464-014-3762-9. Epub 2014 Aug 19. PMID 25135446
- RESULTShindoh J, Seyama Y, Matsuda M, Miyata Y, Shida D, Maeshiro T, Miyamoto S, Inoue S, Umekita N. Continuous ultrasound navigation for safe and precise anatomic resection of the liver. Hepatogastroenterology. 2013 May;60(123):590-4. doi: 10.5754/hge12861. PMID 23282740
- RESULTRethy A, Lango T, Marvik R. Laparoscopic ultrasound for hepatocellular carcinoma and colorectal liver metastasis: an overview. Surg Laparosc Endosc Percutan Tech. 2013 Apr;23(2):135-44. doi: 10.1097/SLE.0b013e31828a0b9a. PMID 23579506
- RESULTMakuuchi M, Hasegawa H, Yamazaki S. Ultrasonically guided subsegmentectomy. Surg Gynecol Obstet. 1985 Oct;161(4):346-50. PMID 2996162
- RESULTGotoh K, Yamada T, Ishikawa O, Takahashi H, Eguchi H, Yano M, Ohigashi H, Tomita Y, Miyamoto Y, Imaoka S. A novel image-guided surgery of hepatocellular carcinoma by indocyanine green fluorescence imaging navigation. J Surg Oncol. 2009 Jul 1;100(1):75-9. doi: 10.1002/jso.21272.