Clinical trial · Observational
Epigenetic Changes in Head and Neck Cancer
Biomarkers in Head and Neck Cancer - Epigenetic Changes and Hypermethylation of Promoter-regions
NCT04260074CI-TRIAL-00052812completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
With this study, the investigators will investigate the epigenetic changes, which may contribute to the development of head and neck squamous cell carcinomas.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Head and Neck Cancer | Malignant Head and Neck Neoplasm | ALIAS | 0.90 |
| Head and Neck Neoplasms | Head and Neck Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Head and Neck Squamous Cell Carcinoma | Head and Neck Squamous Cell Carcinoma | ONTOLOGY_EXACT | 0.98 |
| Squamous Cell Carcinoma | Squamous Cell Carcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (2)
- label
- Oral Cancer group
- description
- 20 consecutive patients with oral squamous cell carcinoma referred to the Department of Otolaryngology - Head and Neck Surgery
- label
- Healthy oral mucosa group
- description
- 20 controls with normal buccal mucosa upon examination.
Primary outcomes (1)
- measure
- Differences in epigenetic changes
- timeFrame
- 6 months
- description
- Differences between tumor- and healthy group
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Cancer group: Inclusion Criteria : * Written informed consent * Histologically confirmed oral squamous cell carcinoma Exclusion Criteria: * History of cancer * Uncontrolled comorbidity Control group: Inclusion Criteria : * Written informed consent * Normal buccal mucosal surface. * Normal ENT-examination Exclusion Criteria: * History of cancer * Uncontrolled comorbidity
References
Publications (0)
Data not yet available
No reference posted for this study.