Clinical trial · Interventional
Primary Cyto-reductive Surgery Vs Neo-adjuvant Chemotherapy (NAC) in Epithelial Ovarian Cancer
Primary Cyto-reductive Surgery Vs Neo-adjuvant Chemotherapy (NAC) Followed by Surgery in Patients With Advanced Primary Epithelial Ovarian Cancer: A Pilot Randomized Study
NCT04257786CI-TRIAL-00043240ovarian cancerunknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Assessment of efficacy of primary cyto-reductive surgery in patients with advanced primary epithelial ovarian cancer in Comparison to patients receiving neo-adjuvant chemotherapy (NAC) followed by surgery in complete excision of the tumor reaching R0 without significant morbidity.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Advanced Cancer | Malignant Neoplasm | CURATED_BROADER | 0.78 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| 1ry cyto-reductive surgery | Procedure | — | UNRESOLVED |
| Neoadjuvant chemotherapy followed by surgery | Combination Product | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Group 1
- description
- 1ry surgery
- interventionNames
- Procedure: 1ry cyto-reductive surgery
- type
- ACTIVE_COMPARATOR
- label
- Group 2
- description
- Neoadjuvant Chemotherapy followed by surgery
- interventionNames
- Combination Product: Neoadjuvant chemotherapy followed by surgery
Primary outcomes (1)
- measure
- Percentage of patient where complete resection of the tumor can be achieved
- timeFrame
- 3 month postoperative
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: Female patients diagnosed with epithelial ovarian cancer (By histopathology) Age ≥ 18 years old Advanced defined as (stage 2D or more ) by surgical staging. Performance status (PS) according to Eastern Cooperative Oncology Group (ECOG) ≤ 2 Chemotherapy naïve Informed consent Exclusion Criteria: Patients previously received chemotherapy or radiotherapy to any part of the abdomen or pelvis. Patients with uncontrolled infection. Patients with active bleeding or conditions associated with high risk of bleeding. contraindications for surgery contraindications To chemotherapy - bevacizumab
References
Publications (1)
- DERIVEDAbutaleb H, Hussien A, Khalaf M, Badary DM, Ismail AM, Hassanein S, AlGizawy S, Moustafa SAM, Farghaly RMM, Abdel-Kawi AF. Primary Cytoreductive Surgery Versus Neoadjuvant Chemotherapy Followed by Surgery in Patients with Advanced Primary Epithelial Ovarian Cancer in Low Resources Setting: A Randomized Clinical Trial. J Obstet Gynaecol India. 2025 Jun;75(3):199-205. doi: 10.1007/s13224-024-02061-w. Epub 2024 Nov 6. PMID 40584804