Clinical trial · Interventional
A Study to Determine Safety and Efficacy of (REMD-477) in Controlling Hyperglycemia Due to Copanlisib
A Phase I/Ib Pilot Study to Determine the Safety and Efficacy of a Human Anti-glucagon Receptor Antibody (REMD-477) in Controlling Severe Hyperglycemia Due to Copanlisib in Patients With Relapsed or Refractory Lymphoma
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): poor accrual
Summary
Brief summary (as posted)
REMD-477 (Volagidemab) is a human anti-glucagon receptor antibody. Its proposed mechanism of action in controlling hyperglycemia is by blocking glucagon receptor (GCGR) signaling. In this way, it increases hepatic glucose uptake, decreases hepatic glycogenolysis and gluconeogenesis, increases glycogen synthesis, and ultimately decreases blood glucose levels. This protocol will test the hypotheses that REMD-477 is safe and tolerable in patients with severe hyperglycemia on copanlisib and that it decreases the risk of severe hyperglycemia in patients receiving copanlisib for relapsed refractory lymphoma
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hyperglycemia Drug Induced | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| REMD-477 | Biological | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- REMD-477
- description
- REMD-477 (human IgG2 anti-glucagon receptor antibody Volagidemab) will be administered as a subcutaneous injection for three weekly doses
- interventionNames
- Biological: REMD-477
Primary outcomes (6)
- measure
- Adverse Events
- timeFrame
- 22 days
- description
- Evaluate the safety of REMD-477 in patients with hyperglycemia due to a PI3 kinase inhibitor
- measure
- Serious Adverse Events
- timeFrame
- 22 days
- description
- Evaluate the safety of REMD-477 in patients with hyperglycemia due to a PI3 kinase
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Age 18 or older * Relapsed or refractory lymphoma (Grade 1, 2, 3A) * Received 2 or more prior lines of systemic therapy for lymphoma * Experienced glucose \>250 mg/dL after copanlisib infusion for treatment of lymphoma Exclusion Criteria: * Evidence of histologic transformation * Follicular Lymphoma Grade 3B * Active CNS involvement by malignancy * Elevated AST or ALT \> 5x ULN at Screening * Unmanageable sensitivity to mammalian-derived drug preparations, or to humanized or human antibodies; managed sensitivities to agents such as obinutuzumab or rituximab or similar agents are not exclusionary * History of drug or alcohol abuse within the last 6 months * History or family history of pancreatic neuroendocrine tumors or multiple endocrine neoplasia * History or family history of pheochromocytoma * Other gastrointestinal, cardiac, renal and CNS (i.e. hypoglycemia unawareness) conditions specific to diabetes that would pose additional risk to subject's safety or interfere with the study evaluation, procedures or completion in the opinion of the treating physician. * Female subject is pregnant or breastfeeding.
References
Publications (0)
Data not yet available