Clinical trial · Interventional
Progressive Resistance Training for the Improvement of Physical Function
A Resistance Training Program to Improve Physical Function in Sarcoma Survivors
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This trial studies how well progressive resistance training works in improving the physical function of sarcoma survivors. Treatments for sarcoma can cause side effects such as fatigue, muscle loss, and weakness, which can negatively impact a patient's ability to physically function and enjoy an independent lifestyle. Engaging in a resistance training exercise routine may improve physical function, body composition, and bone density of sarcoma survivors.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Sarcoma | Sarcoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Exercise Counseling | Other | — | UNRESOLVED |
| Quality-of-Life Assessment | Other | — | UNRESOLVED |
| Questionnaire Administration | Other | — | UNRESOLVED |
| Resistance Training | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Supportive Care (resistance training, exercise counseling)
- description
- Patients complete a series of progressive resistance training exercises at home twice weekly over 1 hour and receive instructional guidance from an exercise physiologist via videoconferencing once per week during one of these sessions for up to 12 weeks.
- interventionNames
- Other: Exercise Counseling
- Other: Quality-of-Life Assessment
- Other: Questionnaire Administration
- Other: Resistance Training
Primary outcomes (3)
- measure
- Retention
- timeFrame
- From the time of enrollment up to 3 months end-of-intervention assessments
- description
- Number of evaluable participants who completed end-of-intervention assessments
- measure
- Exercise Adherence
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 15 Years
Show eligibility criteria text
Inclusion Criteria: * Eligible for the Sarcoma Survivorship Registry (Institutional Review Board \[IRB\] #12039) * History of histologically-confirmed sarcoma * History of treatment with surgery, radiation and/or chemotherapy for the sarcoma diagnosis * Completion of sarcoma treatment \>= 2 years prior to study enrollment * No evidence of recurrent or residual disease on surveillance exam or imaging for at least 2 years prior to study enrollment * Sarcoma location must have been in the extremities, body wall, pelvic/shoulder girdle or axial skeleton. Intra-thoracic, intra-abdominal or cranial sarcomas are not eligible * Currently engaging in \< 1 hour of resistance exercise per week by self-report. Examples of resistance exercise include: using free weights or weight machines, push-ups, sit-ups, lunges, plank, etc. * Able and willing to commit to attending weekly video coaching sessions and independently completing weekly resistance training sessions. This requires access to internet and a device with video and audio capabilities. A webcam may be provided by the study to the participant if needed * Able and willing to commit to attending one initial in-person training session and one in-person follow-up assessment * Ability to understand and willingness to sign a written informed consent document Exclusion Criteria: * Medical contraindication(s) to any and all resistance training as determined by treating physician * Non-English speaking. At this time, we do not have resources to support translation of exercise physiologist (EP) sessions * Dependent on a mobility device (e.g., crutches, wheelchair) for independent activities of daily living (IADLs) * Use of a cane is permitted * Participant has known psychiatric or substance abuse disorders that would interfere with cooperation with the requirements of the trial * Any condition that, in the opinion of the investigator, would interfere with evaluation of study treatment or interpretation of participant safety or study results (e.g., pregnancy)
References
Publications (1)
- DERIVEDDavis LE, Austin SC, Hayden JB, Doung YC, Gundle KR, Ryan CW, Stoyles SA, Winters-Stone KM. Remotely delivered resistance training program in adult sarcoma survivors: a pilot study. BMC Cancer. 2026 Jun 25. doi: 10.1186/s12885-026-16399-z. Online ahead of print. PMID 42343234