Neoadjuvant Chemotherapy in Non Muscle Invasive T1b Bladder Cancer

The aim of our study is to evaluate the benefit of NAC in T1b NMIBC .

Sex

All

Minimum age

18 Years

Maximum age

75 Years

Inclusion Criteria:

1. Patient who are older than 18 years old.
2. Histologically confirmed to have Non-muscle invasive bladder cancer, T1bN0M0 ,clinically and radiologically confirmed to have bladder cancer.
3. Patient should have Eastern Cooperative Oncology Group performances status (ECOG)0-1 with adequate hematologic, hepatic and renal functions including hemoglobin\>10 /dl, absolute neutrophil count ≥1,500/mm3, platelets ≥100,000/mm3, serum bilirubin \<2 mg/dl ,both Alanine transaminase( ALT) and aspartate aminotransferase( AST) ≤2× upper limit of normal (ULN), alkaline phosphates ≤5×ULN,and serum creatinine ≤1.5 mg/dl or creatinine clearance ≥60 ml/min.

Exclusion Criteria:

1. Patients with radiographic evidence of nodal or distant metastases.
2. A past history of upper tract disease, neuroendocrine features.
3. Non-cisplatin-based NAC .
4. Prior radiation therapy to their pelvis.
5. A palpable three-dimensional mass on EUA.
6. Known to be stage 0, T1a, II, III, IV.
7. Active serious infection, or a psychiatric illness that would preclude obtaining informed consent or history of cardiac disease will be excluded.

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