Clinical trial · Observational
IDH1/2 Mutational Analysis in AML Patients: Diagnosis and Follow-up
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
In a spanish series of AML patients it is intended to perform, at the moment of diagnosis, pyrosequencing of IDH1 and IDH2 genes. Taking into account the incidence of AML in the area, it is planed to study 100 patients per year. Among the cases with IDH1/2 mutations, targeted deep sequencing (TDS) of a panel covering coding regions of 40 myeloid related genes will be applied. With TDS, pyrosequencing results will be validated at the same time that prognosis value of co-mutated genes could be studied. Furthermore, with TDS, molecular architecture of IDH1 and IDH2 mutated cases might be better understood.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Acute Myeloid Leukemia | Acute Myeloid Leukemia | CURATED_BROADER | 0.80 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (2)
- label
- IDH1/2 mutated patients
- description
- Patients harboring mutations in IDH1 or IDH2 genes
- label
- Patients without IDH1/2 mutations
- description
- Patients that don´t present any mutation in IDH1/2 genes
Primary outcomes (1)
- measure
- Presence of IDH1/2 mutation
- timeFrame
- 1 day
- description
- Detection of mutations in IDH1 and IDH2 genes
Secondary outcomes (1)
- measure
- Detection of co-mutations
- timeFrame
- 1 day
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients \>18 years old with de novo acute myeloid leukemia will be included. All patients will be treated according to clinical routine. Exclusion Criteria: * Patients not following the above criteria.
References
Publications (0)
Data not yet available