Clinical trial · Interventional
Novel Palliative Care Model for Advanced Cancer Patients: A Randomized Controlled Trial Study
NCT04242251CI-TRIAL-00075652SPARKLE2completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This is a randomized controlled trial of the 'Supportive and Palliative care Review Kit in Locations Everywhere' (SPARKLE) intervention, an outpatient-based model of early palliative care. The SPARKLE intervention comprises regular symptom monitoring using questionnaires, early identification and prompt treatment of problems identified. Proactive screening for problems facilitates earlier palliative care interventions for advanced cancer patients, whenever needs arise.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| SPARKLE Model of care | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- NO_INTERVENTION
- label
- Usual Care
- description
- Management by primary oncologist. Referral to existing palliative care service initiated by primary oncologist if needed.
- type
- EXPERIMENTAL
- label
- SPARKLE intervention group
- description
- Regular symptom monitoring and treatment of problems identified. Referral to existing palliative care services can also be initiated by the SPARKLE nurse if identified problems require follow up.
- interventionNames
- Other: SPARKLE Model of care
Primary outcomes (1)
- measure
- Functional Assessment of Cancer Therapy- General
- timeFrame
- 16 weeks
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 21 Years
- Maximum age
- 120 Years
Show eligibility criteria text
Patient participants Inclusion Criteria: * Adult aged 21 and above * Stage 4 solid tumor Patient participants Exclusion Criteria: * Unable to complete patient-reported outcome measures * Already under the care of an existing palliative care service Caregiver participants Inclusion Criteria: \- Adult aged 21 and above Caregiver participants Exclusion Criteria: * Unable to complete Singapore Caregiver Quality of Life Scale questionnaire * Employed caregiver to patient participants
References
Publications (2)
- DERIVEDYang GM, Ke Y, Ng XH, Neo PSH, Cheung YB. Proactive symptom monitoring to initiate timely palliative care for patients with advanced cancer: a randomized controlled trial. Support Care Cancer. 2025 Mar 5;33(3):249. doi: 10.1007/s00520-025-09311-1. PMID 40038129
- DERIVEDYang GM, Lee Y, Ke Y, Neo PSH, Cheung YB. Feasibility of Weekly Integrated Palliative Care Outcome Scale (IPOS) Within a Stepped Care Model. J Pain Symptom Manage. 2024 Sep;68(3):e174-e182. doi: 10.1016/j.jpainsymman.2024.06.004. Epub 2024 Jun 13. PMID 38878909