Clinical trial · Interventional
Quantitative Assessment of Blood Supply in the Gastic Conduit With Fluorescence Angiography for Esophageal Reconstruction
Quantitative Assessment of the Correlation Between Blood Supply in the Gastic Conduit and the Incidence of Anastomotic Fistula With Fluorescence Angiography for Esophageal Reconstruction
NCT04229524CI-TRIAL-00045453unknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
A single-institution, randomize controlled trial is to be held to evaluate the correlation between blood supply in the gastic conduit and the incidence of anastomotic fistula during radical operation for esophageal squamous cell carcinoma by fluorescence angiography.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Esophageal Squamous Cell Carcinoma | Esophageal Squamous Cell Carcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Fluorescence angiography | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- angiographic intervention group
- description
- Enrolled patients will undergo thoracoscopy combined with a three-incision esophageal carcinoma radical mastectomy and two-field (chest-abdomen) lymph node dissection.Quantitative assessment of blood supply in the gastic conduit was performed using fluoroscopy before esophagogastric anastomosis.
- interventionNames
- Procedure: Fluorescence angiography
- type
- NO_INTERVENTION
- label
- control group
- description
- The same surgical method as the experimental group.The only difference is that the position of the gastic conduit anastomosis is determined based on the experience of the doctor.
Primary outcomes (1)
- measure
- The incidence of anastomotic fistula
- timeFrame
- 3 months
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * 1.Histologically confirmed esophageal squamous cell carcinoma and and potential resection; * 2.Intend to undergo thoracic laparoscopy combined with three-incision esophageal cancer radical operation; * 3.The stomach is used as an esophageal substitute for reconstruction; * 4.Enrolled patients will adopt the esophagus bed pathway and round neck anastomosis method; * 5.Have a performance status of 0 or 1 on the ECOG Performance Scale; Adequate organ function; * 6.Be willing and able to provide written informed consent/assent for the trial. Exclusion Criteria: * 1.Histologically confirmed non-squamous cell carcinoma of the esophagus ; * 2.The ECOG score of patient's physics \>1; * 3.Patients who use other organs instead of the esophagus; * 4.Patients with vascular arch injury and need vascular anastomosis; * 5.Patients with multiple complications such as heart disease or diabetes; * 6.Other patients whom the medical practitioner considers inappropriate for inclusion.
References
Publications (1)
- DERIVEDHe W, Li Z, Deng X, Zheng K, Wang C, Peng L, Han Y, Leng X, Zhou Q. Fluorescence quantitative assessment of blood perfusion in the gastric conduit to reduce anastomotic leakage after esophagectomy: a randomized controlled trial. Surg Endosc. 2025 Oct;39(10):6644-6654. doi: 10.1007/s00464-025-12093-6. Epub 2025 Aug 20. PMID 40835759