Clinical trial · Interventional
A Comparison Between Ivor-Lewis and McKeown Minimally Invasive Esophagectomy
A Comparison of Short-term and Long- Term Outcomes Between Ivor-Lewis and McKeown Minimally Invasive Esophagectomy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Surgery is still the main treatment for esophageal cancer, however, the complication and mortality rate of open esophagectomy is high. As a result, the thoracoscopic- laparoscopic minimally invasive esophagectomy (MIE) was developed. The MIE mainly comprised two surgical approaches: MIE McKeown approach (cervical anastomosis) and MIE Ivor-Lewis approach (intrathoracicanastomosis). The MIE with intrathoracic anastomosis (Ivor-Lewis) is increasingly used for the treatment of mid and lower esophageal cancers. Our study is trying to compare the safety, feasibility, and short-term and long- term outcomes between MIE Ivor-Lewis approach and MIE McKeown approach for the treatment of lower thoracic esophageal cancer and esophageal- gastric junction.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Esophageal Cancer | Malignant Esophageal Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| MIE Ivor- Lewis | Procedure | — | UNRESOLVED |
| MIE McKeown | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Ivor-Lewis group
- description
- minimally invasive esophagectomy (MIE) with intrathoracic anastomosis
- interventionNames
- Procedure: MIE Ivor- Lewis
- type
- ACTIVE_COMPARATOR
- label
- McKeown group
- description
- minimally invasive esophagectomy (MIE) with cervical anastomosis
- interventionNames
- Procedure: MIE McKeown
Primary outcomes (1)
- measure
- Overall postoperative complications
- timeFrame
- within one month
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 30 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: (I) Patients with clinically staged T1-3N0-2M0 tumors; good cardiopulmonary function; (II) Patients with lower thoracic esophageal tumors and esophageal- gastric junction tumor; (III) Patients without a previous history of cancer; (IV) Patients without a previous history of neck or chest surgery; Exclusion Criteria: (I) cardiopulmonary function not good enough for surgery; (II) Patients with hybrid MIE
References
Publications (1)
- DERIVEDZhao Y, Shan L, Peng C, Cong B, Zhao X. Learning curve for minimally invasive oesophagectomy of oesophageal cancer and survival analysis. J Cardiothorac Surg. 2021 Nov 10;16(1):328. doi: 10.1186/s13019-021-01712-7. PMID 34758861