Detecting Cancers Earlier Through Elective Plasma-based CancerSEEK Testing

Inclusion Criteria:

* Age 50 or greater
* Ability to understand the nature of this study and give written informed consent

CANCER COHORT:

Either of the following:

* Histologic diagnosis of cancer with no prior systemic or definitive therapy (any stage, including, inclusive of is-situ carcinoma)

Or

* Subject with high suspicion of cancer through radiological and/or clinical assessment who are scheduled for resection or biopsy within 6 weeks of study blood collection and have not received prior systemic or definitive therapy.

NON-CANCER COHORT

* No prior history of cancer

Exclusion Criteria:

ALL PATIENTS

* Evidence of active febrile infection prior to blood draw.
* Women who are pregnant or breast-feeding.
* History of an allogeneic bone marrow, stem cell transplant, or solid organ transplant.
* Judgment by the Investigator or study staff of any other reason that would prohibit the inclusion of the subject in the study.

CANCER COHORT

* Subjects newly diagnosed with a hematologic malignancy, primary central nervous system tumor, prostate cancer, or skin cancer (including melanoma).
* History of, or currently receiving, systemic or definitive cancer treatment including curative surgical resection, chemotherapy, radiation therapy, immunotherapy, and hormone therapy.

NON-CANCER COHORT

• None