Clinical trial · Interventional
Effect of Salt Solution Immersion Bath on Cancer in Vivo.
Effect of Human Body Immersion in Hypertonic Saline Solution on Cancer Nodules' Size, Number and Its Metastasis Properties in Vivo.
NCT04210726CI-TRIAL-00068325withdrawnN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Working on complying with the Research Ethics Board requirements.
Summary
Brief summary (as posted)
This Study evaluates the effectiveness of Hypertonic Saline Bath in reducing the Cancer nodules' size, number and SUVmax.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| 0.9% Isotonic Saline Bath | Other | — | UNRESOLVED |
| 25% Hypertonic Saline Bath | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Active Group - 25% Saline Bath
- description
- The Active group's patients will separately have an immersion bath in 25% Sea Salt in Water solution (made by adding pure Sodium Chloride in the form of Sea Salt to Tap Water Bath) at a temperature comfortable to every participant (please note that Solubility of Sodium Chloride in Water does not change significantly with change in temperature, therefore the concentration will remain the same regardless of water temperature), whereas the bath solution is in direct contact with the skin, for 30 minutes once daily for 7 consecutive days, in addition to their standard treatments they receive from their health care providers.
- interventionNames
- Drug: 25% Hypertonic Saline Bath
- type
- PLACEBO_COMPARATOR
- label
- Control Group - 0.9% Saline Bath
- description
- The Control group's patients will separately have a bath in 0.9% Sea Salt in Water (Isotonic solution, made by adding Sodium Chloride in form of Sea Salt to Tap Water) at a comfortable temperature whereas the bath solution is in direct contact with the skin, for 30 minutes once daily for 7 consecutive days, in addition to their standard treatments they receive from their health care providers
- interventionNames
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 5 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Patients with PET/CT scan-confirmed Cancer (any type, any location and any stage) who have poorly responded to at least one cycle of conventional and standard therapy (Chemotherapy, Radiation or Drug therapy) . * Age 5 to 80 years old * Life expectancy of at least 1 year * Can understand and read English * Lives in Calgary Alberta Exclusion Criteria: Patients with the following medical conditions will be excluded: 1. Kidney diseases 2. Dialysis 3. Fever 4. On Blood Thinners or with any Coagulation disorder 5. History of stroke 6. Hypernatraemia 7. Hypotension (Low Blood Pressure) 8. Hypovolemia/Dehydration 9. Tachycardia (Rapid Heart rate) 10. Epilepsy 11. Open wounds 12. Any medical condition that might cause the patient to lose consciousness 13. Participants who cannot tolerate thirst during the 30 minutes bath. 14. Participants who are not residents of Calgary Alberta Canada with a valid Alberta Health Card.
References
Publications (2)
- BACKGROUNDMcIntyre GI. Cell hydration as the primary factor in carcinogenesis: A unifying concept. Med Hypotheses. 2006;66(3):518-26. doi: 10.1016/j.mehy.2005.09.022. Epub 2005 Nov 3. PMID 16271440
- BACKGROUNDMachado M, Salgado TM, Hadgraft J, Lane ME. The relationship between transepidermal water loss and skin permeability. Int J Pharm. 2010 Jan 15;384(1-2):73-7. doi: 10.1016/j.ijpharm.2009.09.044. Epub 2009 Sep 30. PMID 19799976