Clinical trial · Interventional
Analysis of Vestibular Compensation Following Clinical Intervention for Vestibular Schwannoma
Temporal Synthesis of Vestibular and Extra-Vestibular Sensory Signals
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Following further collection and analysis of temporal binding data, we found the relationship between PSS and clinical outcomes to not be strong enough for adaptation.
Summary
Brief summary (as posted)
Multiple sensory cues are typically generated by discrete events, and while they do not reach the cerebrum simultaneously, the brain can bind them temporally if they are interpreted as corresponding to a single event. The temporal binding of vestibular and non-vestibular sensory cues is poorly understood and has not been studied in detail, despite the fact that the vestibular system operates in an inherently multimodal environment. In this study, the researchers are investigating the physiology and pathophysiology of vestibular temporal binding by studying normal subjects, patients with peripheral and central vestibular dysfunction, and patients with vestibular and cochlear signals provided by prosthetic implants in the inner ear.
Conditions
Conditions (6)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Dizziness | — | UNRESOLVED | — |
| Migraine | — | UNRESOLVED | — |
| Motion Sickness | — | UNRESOLVED | — |
| Vestibular Disorder | — | UNRESOLVED | — |
| Vestibular Migraine | — | UNRESOLVED | — |
| Vestibular Schwannoma | Vestibular Schwannoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Chronic Motion-modulated Stimulation | Behavioral | — | UNRESOLVED |
| Temporal Binding Adaptation - PSS adaptation with VI stimulation | Behavioral | — | UNRESOLVED |
| Temporal Binding Adaptation - PSS training | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (5)
- type
- NO_INTERVENTION
- label
- Normal Controls
- description
- normal control subjects - no history of neurologic or inner ear disease The investigators will characterize vestibular spatial and temporal precision by calculating perceptual thresholds for vestibular (yaw rotation) stimuli in normal subjects over a wide age range. Vestibular-visual temporal binding is then performed on each subject and the relationship between the principal parameters (vestibular perceptual thresholds \[inversely related to spatial precision\] and the PSS and TBW from the temporal binding paradigm) will be examined. The investigators will collect qualitative assessments of dizziness/disbalance (DHI: dizziness handicap index) and quantitative measurements of balance and vestibular function (FGA: functional gait analysis, postural sway, and standard rotational testing - VOR gain, time constant, asymmetry).
- type
- NO_INTERVENTION
- label
- Central Vestibular Dysfunction
- description
- Migraine and Vestibular Migraine patients The investigators intend to evaluate vestibular (yaw rotation) - visual temporal binding in people with a wide range of motion sickness sensitivities (as quantified with standard questionnaires), including normal subjects, people with migraine and with vestibular migraine.
- type
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 8 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: Normal subjects * normal vestibular-oculomotor exams * normal low-frequency standard rotational testing * normal hearing Migraine * meets International Headache Society (IHS) criteria for migraine with or without aura * tested more than 2 weeks after most recent migraine headache Vestibular Migraine * meets Barany Society criteria for vestibular migraine, which includes: * episodic vestibular symptoms that occur with headaches that meet the IHS criteria for migraine * tested more than 2 weeks after most recent migraine headache or vestibular episode Vestibular Schwannoma * existence of unilateral vestibular schwannoma (pre \& post clinical intervention e.g. surgical resection) * must plan to have clinical intervention such as sub-occipital surgical approach with complete sectioning of the vestibular nerve * rotational testing to assess pre-surgical vestibular function * audiogram * brain MRI consistent with vestibular schwannoma * audiography in each ear Vestibular (VI) and Cochlear (CI) Implant subjects * scheduled for CI surgery because of deafness * minimum 5 year history of documented absence of auditory and vestibular function, based on review of their audiograms and vestibular tests * specific vestibular criteria: peak ice water caloric response of less than 3deg/s for each ear; yaw VOR time constant \<3s and gain \<0.25; and reduced head impulse gain (\<0.25) for all canal planes * specific audiographic criteria: 80dB or greater sensorineural hearing loss in both ears Exclusion Criteria: Normal subjects * history of otologic or neurologic disease * on vestibular suppressant medication (benzodiazepine, antihistamine, anticholinergic) * pregnant or recently (\<6mos) pregnant Migraine * history of vestibular symptoms (other than motion sickness) * evidence of other neurologic or otologic dysfunction * on migraine prophylactic medications * on vestibular suppressant medication (benzodiazepine, antihistamine, anticholinergic) Vestibular Migraine (VM) * other neurologic or otologic dysfunction as defined above except for central eye movement findings that are consistent with VM and therefore not exclusionary. * on migraine prophylactic medication * on vestibular suppressant medication (benzodiazepine, antihistamine, anticholinergic) Vestibular Schwannoma * other otologic disease (other than presbycusis) or any neurologic disease (other than migraine) * on vestibular suppressant medication (benzodiazepine, antihistamine, anticholinergic)
References
Publications (0)
Data not yet available