Clinical trial · Interventional
Postoperative Heme Oxygenase Induction and Carbon Monoxide Production as a Novel Method to Assess Hepatic Regeneration and Predict Hepatic Related Morbidity After Partial Hepatectomy
Postoperative Heme Oxygenase Induction and Carbon Monoxide Production as a Novel Method to Assess Hepatic Regeneration and Predict Hepatic Related Morbidity After Partial Hepatectomy-1301GCC
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The study will monitor carbon monoxide production in patients undergoing liver resection. Carbon monoxide will be checked from arterial blood gas obtained routinely as a part of the postoperative care as well as from the exhaled air of the patient through a CO detector commercially available and used as smokerlyzer helping people to stop smoking. The results of the surgical resection will be collected from the patient routinely ordered tests after liver resection including pathology of the resected part of the liver, laboratory and radiology tests. The study aims to identify the relationship between CO production and recovery after liver resection. Results of this study may help in predicting and improving results of liver resection.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Liver Cancer | Malignant Liver Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| ABG Testing Pre/Post Hepatic Resection | Diagnostic Test | — | UNRESOLVED |
| CO Testing Pre/Post Hepatic Resection | Procedure | — | UNRESOLVED |
| CT Evaluations | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- OTHER
- label
- Intervention Arm
- description
- CO and ABG Testing Arm
- interventionNames
- Procedure: CO Testing Pre/Post Hepatic Resection
- Diagnostic Test: ABG Testing Pre/Post Hepatic Resection
- Diagnostic Test: CT Evaluations
Primary outcomes (6)
- measure
- CO Output (Ppm)
- timeFrame
- Baseline
- description
- Measure HO-1 induction by measuring endogenous CO production in relationship to the extent of hepatic resection
- measure
- ABG (COHb)
- timeFrame
- Baseline
- description
- Measure HO-1 induction by measuring endogenous CO production in relationship to the extent of hepatic resection
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients plan to have partial liver resection for primary liver pathology or metastatic disease. * Patients able to comprehend and willing to sign the written consent form. Exclusion Criteria: * Patients age less than 18 * Patients not having pathology proven liver malignancy * Patient not able to comprehend or sign written consent form.
References
Publications (0)
Data not yet available