Clinical trial · Interventional
Determining Normal Range for Free Light Chains in Serum Among Twins
Normal Range Study for Free Light Chains in Blood Among Identical or Fraternal Twins
NCT04191057CI-TRIAL-00084652completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The objective of this study is to recruit healthy adult identical and fraternal twins for the collection of one teaspoon of blood to be sent to the Clinical Lab at San Francisco General Hospital. The serum will be tested to determine the reference range for free light chains.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Multiple Myeloma | Multiple Myeloma | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Free light chains | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Healthy twin
- description
- Free light chains of twins compared to non-twin siblings
- interventionNames
- Other: Free light chains
Primary outcomes (1)
- measure
- Free light chain reference range
- timeFrame
- One month after the completion of the enrollment
- description
- Determination of the normal range for free light chains
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Healthy subjects 18-80 years. * Must be an identical or fraternal twin (both must be recruited) Exclusion Criteria: * Symptoms suggestive of multiple myeloma (e.g., renal insufficiency, anemia, bone pain) -
References
Publications (2)
- BACKGROUNDBraga F, Infusino I, Dolci A, Panteghini M. Biological variation of free light chains in serum. Clin Chim Acta. 2013 Jan 16;415:10-1. doi: 10.1016/j.cca.2012.09.008. Epub 2012 Sep 11. No abstract available. PMID 22981867
- BACKGROUNDKatzmann JA, Clark RJ, Abraham RS, Bryant S, Lymp JF, Bradwell AR, Kyle RA. Serum reference intervals and diagnostic ranges for free kappa and free lambda immunoglobulin light chains: relative sensitivity for detection of monoclonal light chains. Clin Chem. 2002 Sep;48(9):1437-44. PMID 12194920