Clinical trial · Observational
Sleep Apnoea Syndrome and Hepatocellular Carcinoma
Evaluation of the Prevalence of Sleep Apnea Syndrome in Patients With Hepatocellular Carcinoma
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): the possibility of obtaining histological data is too low due to the lack of availability of biological samples
Summary
Brief summary (as posted)
Obstructive sleep apnea (OSA), one of the most frequent respiratory diseases, could represent a major worsening factor in a non alcoholic steatohepatitis and neoplastic context. Our hypothesis is that OSA promotes the prevalence of HCC related to NASH. This national, multicenter study aims to compare the prevalence of OSA in a group of patient curatively resected for NASH-related HCC with a group of HCV-related HCC.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hepatocellular Carcinoma | Hepatocellular Carcinoma | ONTOLOGY_EXACT | 0.98 |
| Non Alcoholic Steato Hepatitis | — | UNRESOLVED | — |
| Sleep Apnea, Obstructive | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Nocturnal oximetry | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- NASH-related HCC
- description
- The study is focused on patients suffering from NASH-induced HCC. Each patient with NASH-related HCC will be paired with 2 patients with non NASH-related HCC (HCV-induced CHC).
- interventionNames
- Diagnostic Test: Nocturnal oximetry
- label
- HCV-related HCC
- description
- HCV-related HCC has been chosen as control population for several reasons: HCV represent a common etiology of HCC; with a distinct pathophysiology distinct from that of post-NASH HCC; populations with post-NASH and post-HCV CHC share similar epidemiological characteristics.
- interventionNames
- Diagnostic Test: Nocturnal oximetry
Primary outcomes (1)
- measure
- The study will compare OSA prevalence in a group of patient curatively resected for NASH-related HCC with a group of HCV-related HCC.
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Man and woman * \>18 years * Diagnosis of NASH-induced HCC or HCV-induced HCC * Patients treated by surgical excision * Patients not opposed to the study Exclusion Criteria: * Patient refusal * Alcohol consumption\> 20g / day for women and\> 30g / day for men * Patient with HCV genotype 3 * Tumor vascular invasion identified preoperatively * Other etiologies of hepatopathies (alcoholic, viral B, autoimmune, hemochromatosis) * Other chronic respiratory diseases: chronic obstructive pulmonary disease, respiratory insufficiency * Patient weight variation \>5% since surgical treatment of his HCC * Subject deprived of liberty or under guardianship
References
Publications (0)
Data not yet available