Clinical trial · Observational
Molecular Signatures of HPV+ ORL Cancers (OROPAP)
Identification of Specific Molecular Signatures by Capture-HPV and Next-generation Sequencing in HPV-induced Oropharyngeal Cancers
NCT04189003CI-TRIAL-00054240OROPAPcompletedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The aim of this study is to identify HPV molecular signature in head and neck cancer to establish a new classification for positive human papillomavirus oropharyngeal tumor
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Human Papillomavirus-Related Carcinoma | Human Papillomavirus-Related Carcinoma | ONTOLOGY_EXACT | 0.98 |
| Oropharyngeal Cancer | Malignant Oropharyngeal Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Description the HPV molecular signatures identified by the Capture-HPV technique and comparison of these signatures with those already described in the classification described in the Holmes et al. in the cervix
- timeFrame
- 18 months
- description
- Establish a new classification based on HPV molecular signature for positive human papillomavirus oropharyngeal tumor
Secondary outcomes (6)
- measure
- Quantification of HPV circulating tumoral DNA in peripheral blood by droplet based digital PCR
- timeFrame
- 18 months
- description
- Find in the peripheral blood of patients, the presence of circulating tumoral HPV DNA (ctDNA) by droplet based digital PCR and when it is possible compare chromosomal insertion patterns of HPV ct DNA as those found in tumors
- measure
- Correlate identified HPV molecular signature with clinical-anatomo-pathological data.
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients with HPV + oropharyngeal cancer Exclusion Criteria: * NA
References
Publications (0)
Data not yet available
No reference posted for this study.