Clinical trial · Interventional
Cefepime vs Ceftazidime as Empirical Therapy for Neutropenic Fever
Cefepime vs Ceftazidime as Empirical Therapy for Neutropenic Fever in Pediatric Acute Leukemia: Review of Temperature and Absolute Neutrophil
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Empirical antibiotic therapy has been known to reduce the mortality and morbidity rate in neutropenic fever. Until now, ceftazidime was the first line choice of neutropenic fever. However, resistance against ceftazidime has been reported. Several countries have reported cefepime in reducing fever and shorten the length of hospitalization better than ceftazidime. This study is aimed to compare the effectivity of ceftazidime and cefepime to reduce fever and to increase the absolute neutrophils count (ANC) in the first 72 hours.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Antibiotic Reaction | — | UNRESOLVED | — |
| Leukemia | Leukemia | ONTOLOGY_EXACT | 0.90 |
| Neutropenia, Febrile | — | UNRESOLVED | — |
| Pediatric Cancer | Childhood Malignant Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Cefepime Injection | Drug | — | UNRESOLVED |
| Ceftazidime Injection | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Group I
- description
- Participants were given ceftazidime as the antibiotic therapy with standard regimens and dose of antibiotic
- interventionNames
- Drug: Ceftazidime Injection
- type
- EXPERIMENTAL
- label
- Group II
- description
- Participants were given cefepime as the antibiotic therapy with standard regimens and dose of antibiotic
- interventionNames
- Drug: Cefepime Injection
Primary outcomes (2)
- measure
- Temperature decrease
- timeFrame
- after 72 hours of antibiotic adminstration
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 1 Year
- Maximum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * children with leukemia aged 1 month to 18 years old undergoing chemotherapy * having fever of ≥ 38,3 0C in axillar temperature * ANC \< 1000/mm3 * patients' parents or guardians must be willing to participate and willing to sign a written informed consent form Exclusion Criteria: * patients with a history of penicillin or cephalosporin allergy * patients with kidney dysfunction
References
Publications (0)
Data not yet available