Clinical trial · Interventional
Nasal Inhalation of Isopropyl Alcohol for the Treatment of Nausea in Patients With Cancer
Inhalation Approaches to Nausea: A Randomized Controlled Trial
NCT04181463CI-TRIAL-00112724not yet recruitingPhase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this research study is to understand the effect of inhalation approaches in reducing nausea in cancer patients.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Malignant Neoplasm | Malignant Neoplasm | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Isopropyl Alcohol | Drug | — | UNRESOLVED |
| Placebo | Other | — | UNRESOLVED |
| Questionnaire Administration | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Arm I (isopropyl alcohol)
- description
- Patients receive isopropyl alcohol via nasal inhalation.
- interventionNames
- Drug: Isopropyl Alcohol
- Other: Questionnaire Administration
- type
- PLACEBO_COMPARATOR
- label
- Arm II (placebo)
- description
- Patients receive placebo via nasal inhalation.
- interventionNames
- Other: Placebo
- Other: Questionnaire Administration
Primary outcomes (1)
- measure
- Change in nausea
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Rate current severity of acute/chronic nausea \>= 4 on NRS (Numeric Rating Scale) * Diagnosis of cancer * Able to read/write in English * Referred to supportive care service as an inpatient or outpatient * Rate anxiety as =\< 4 on ESAS-FS (Edmonton Symptom Assessment Scale-Financial Distress and Spiritual Pain) * Participants must agree to inhale isopropyl alcohol Exclusion Criteria: * Received anti-emetics in the last 30 minutes * Received medical procedures (e.g. blood draws) which required exposure of isopropyl alcohol in the last 30 minutes * Inability to inhale through nares (including recent upper respiratory infection) * Known allergy to isopropyl alcohol * Delirium (i.e., score \>= 7 on the Memorial Delirium Assessment Scale \[MDAS\]) * Have never been on anti-emetics during the course of the treatment here (anti-emetic naive)
References
Publications (0)
Data not yet available
No reference posted for this study.