Study of LUCAR-20S in Patients With R/R NHL

Inclusion Criteria:

1. Signed informed consent form (ICF)
2. Age 18 Years to 75 Years
3. Pathological diagnosis of refractory/relapsed CD20+ non-Hodgkin's lymphoma (one of the following):

   1. Diffuse large B-cell lymphoma (DLBCL)
   2. Follicular lymphoma (FL)
   3. Mantle cell lymphoma (MCL)
   4. Small lymphocytic lymphoma (SLL)
4. Measurable disease as defined by 2014 Lugano criteria at Screening
5. Refractory/relapsed disease after standard-of- care treatment as following (Undergone at least 2 complete cycle of therapy for each line, unless PD been documented as the best response to the regimen) and not eligible or appropriate for HSCT (Auto/allo). Subject must have documented evidence of progressive disease on or within 12 months of their last regimen.

   1. DLBCL: Refractory/relapsed after at least 1 prior line of therapy, must have been treated with anti-CD20 monoclonal antibody
   2. FL: Refractory/relapsed after at least 2 prior lines of therapy, must have been treated with anti-CD20 monoclonal antibody
   3. MCL: Refractory/relapsed after at least 2 prior lines of therapy
   4. SLL: Refractory/relapsed after at least 2 prior lines of therapy
6. Laboratory criteria at Screening

   ① Blood routine: NE≥1.0×109/L；HGB≥8g/dL；PLT≥50×109/L

   ② Blood biochemical parameters:
   1. Total bilirubin ≤ 1.5 times of the normal upper limit (ULN)
   2. Aspartate and alanine aminotransferases (AST, ALT) ≤ 3 times ULN (in the presence of liver metastasis, ULN 5 times)
   3. Estimated glomerular filtration rate (eGFR) \> 60mL/min
7. Life expectancy \> 12 weeks
8. Eastern Cooperative Oncology Group (ECOG) Performance Status grade of 0 or 1

Exclusion Criteria:

1. Any malignancy besides the NHL categories under study, exceptions include

   1. Any other malignancy curatively treated and disease-free for at least 2 years prior to enrollment
   2. History of non-melanoma skin cancer with sufficient treatment and currently no evidence of recurrence
2. Prior treatment with an allogeneic stem cell transplant
3. Prior treatment with genetic therapy
4. Prior treatment with chimeric antigen receptor T (cells) CAR-T therapy directed at CD20 target
5. Those who are positive for any index of hepatitis B surface antigen (HBsAg), hepatitis B virus deoxyribonucleic acid (HBV DNA), hepatitis C antibody (HCV-Ab), hepatitis C virus ribonucleic acid (HCV RNA), and human immunodeficiency virus antibody (HIV-Ab)
6. Prior antitumor therapy with insufficient washout period

   1. Targeted therapy, epigenetic therapy, experimental drug therapy or experimental invasive treatment with medical apparatus and instruments 14 days or five half-lives, whichever is shorter before lymphodepletion
   2. Use of monoclonal antibodies 21 days prior to lymphodepletion
   3. Chemotherapy within 14 days prior to lymphodepletion
   4. Radiotherapy within 14 days prior to lymphodepletion
   5. Participated in other clinical trials within 30 days prior to lymphodepletion
7. With central nervous system involvement
8. Women in pregnancy or lactation
9. Being fertile and unable to use effective conception during treatment and 100 days after CAR-T infusion
10. Active autoimmune disease or history of autoimmune disease within 3 years
11. With obvious hemorrhagic tendency such as gastrointestinal hemorrhage, coagulation disorders and hypersplenism
12. The following cardiac conditions

    1. New York Heart Association (NYHA) stage III or IV congestive heart failure
    2. Left ventricular ejection fraction (LVEF) less than (\<)45%
    3. Uncontrolled cardiac arrhythmia post-medication
    4. With a history of myocardial infraction or unstable angina pectoris within the past 6 months
    5. Constrictive pericarditis
    6. Cardiomyopathy
13. Pulse oximetry of \<96% on room air
14. Active or uncontrolled infection requiring parenteral antibiotics, or any evidence of severe active viral/bacterial infection or uncontrolled systemic fungal infection
15. Uncontrolled diabetes mellitus, defined as fast serum glucose \> 1.5 times ULN
16. Concurrent use of corticosteroids or other immunosuppressant medications for chronic disease
17. Concurrent use of hematopoietic growth factor
18. Stroke or seizure within 6 months of signing ICF
19. Have received any live, attenuated vaccine within 4 weeks prior to lymphodepletion
20. Have underwent major surgical operation within 2 weeks prior to lymphodepletion, or anticipate to undergo a major surgical operation during the study process or within 2 weeks posterior to study treatment(with the exception of anticipated local anesthesia surgery)
21. Known life threatening allergies, hypersensitivity, or intolerance to LUCAR-20S CAR-T cells or its excipients, including dimethyl sulfoxide (DMSO)
22. Presence of any condition that, in the opinion of the investigator, would prohibit the patient from undergoing treatment under this protocol