Clinical trial · Observational
Child's Study of the Impact of PF Lesion on Motor Skills, Language, Cognitive Functioning and Social Cognition
Child's Study of the Distant Impact of Posterior Fossa Injury on Motor Skills, Language, Cognitive Functioning, and Social Cognition - a Combination of Clinical Assessments and Brain Imaging
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
One of the major complications of posterior fossa surgery is Posterior Fossa Syndrome (PFS). This syndrome is due to a possible complication of surgical excision of a tumor of the cerebellum (4th ventricle) and is characterized by transient postoperative mutism, dysarthria, behavioral, and affective disorders, as well as motor disorders. PFS is thought to be related to axonal lesions. The long-term consequences on the cognitive and psychosocial sphere of PFS have been widely documented. On the other hand, the literature concerning the consequences of this syndrome on language is much restricted. Beyond the language, the role of cerebellum would be central in cognition, some authors even comparing it to a great "conductor" who would underlie the learning of most motor and cognitive automatisms.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Fossa Posterior Tumor | — | UNRESOLVED | — |
| Healthy Volunteers | — | UNRESOLVED | — |
| Low-grade Glioma | Low Grade Glioma | ONTOLOGY_EXACT | 0.98 |
| Medulloblastoma, Childhood | Childhood Medulloblastoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Functional Magnetic Resonance Imaging (fMRI) | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- label
- Retrospective Low-Grade Glioma
- description
- Inclusion of patients with Low-Grade Glioma treated one year ago, with functional Magnetic Resonance Imaging, speech therapy, neuropsychological, balance and dexterity tests
- interventionNames
- Other: Functional Magnetic Resonance Imaging (fMRI)
- label
- Retrospective Medulloblastoma
- description
- Inclusion of patients with Medulloblastoma treated one year ago, with functional Magnetic Resonance Imaging, speech therapy, neuropsychological, balance and dexterity tests
- interventionNames
- Other: Functional Magnetic Resonance Imaging (fMRI)
- label
- Prospective patients
- description
- Inclusion of prospective patients with an indication to surgery of a Posterior Fossa Tumor, with evaluation of post-operative mutism and then one year after the end of mutism, an evaluation with functional Magnetic Resonance Imaging, speech therapy, neuropsychological, balance and dexterity tests
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 6 Years
- Maximum age
- 17 Years
Show eligibility criteria text
Inclusion Criteria: * Patient with a low grade glioma of the posterior fossa or a medulloblastoma * Healthy volunteers without any tumor in the posterior fossa (control case) * At one year of the last treatment for the retrospective groups, or patient who have an indication to a surgery of a tumor of the posterior fossa * Eligibility to a functional MRI * Informed consent dated and signed by the holder of the parental authority (if minor) or by the patient (if major) to take part in the study * Affiliated to a Social Security scheme Exclusion Criteria: * Antecedent of neurologic, metabolic or genetic disease * Brainstem glioma * Have a contraindication to a MRI
References
Publications (0)
Data not yet available