Clinical trial · Observational
How Does Prostate Cancer Metastasize? Studying the Role of Secreted Packages (Exosomes) From Fat Tissue in Lean and Obese Patients
The EXOPRO Study: How Does Prostate Cancer Metastasize? Understanding the Role of Exosomal Communication in Lean vs Obese Patients
NCT04167722CI-TRIAL-00054031EXOPROunknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The investigators will be collecting prostate and fat tissue from participants undergoing radical prostatectomy to culture and study in the laboratory.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Obesity | — | UNRESOLVED | — |
| Prostate Cancer | Malignant Prostate Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Robotic Radical Prostatectomy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Obese patients
- description
- BMI \> 25
- interventionNames
- Procedure: Robotic Radical Prostatectomy
- label
- Lean patients
- description
- BMI \< or = 25
- interventionNames
- Procedure: Robotic Radical Prostatectomy
Primary outcomes (4)
- measure
- Determine functional differences of peri-prostatic adipose tissue from lean vs obese patients on prostate cancer cell lines
- timeFrame
- Through to study completion, on average 3 years
- description
- Proliferation, migration, invasion, apoptosis and epthelial-mesenchymal transition assays will be performed using isolated exosomes on prostate cancer cell lines
Eligibility
Eligibility (as posted)
- Sex
- Male
Show eligibility criteria text
Inclusion Criteria: * All men undergoing radical prostatectomy at Charing Cross Hospital Exclusion Criteria: * Patients unable to consent
References
Publications (0)
Data not yet available
No reference posted for this study.