Clinical trial · Observational
Impact of HPV Vaccination on Cervical High Grade Lesions in France
Impact of HPV Vaccination on the Distribution of HPV in High Grade Lesions of the Cervix in France
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The objective is to estimate the prevalence of the different genotypes of human papillomaviruses (HPV) in histologically proven high-grade lesions of the cervix in patients born between 1972 and 1993. It is plan to determine if the prevalence of HPV16 and HPV18 is lower in the population born between 1983 and 1993 and potentially exposed to HPV vaccination compared to those born between 1972 and 1982 who were not exposed to vaccination. Thus the investigators should be able to determine whether the introduction of HPV vaccination in France in 2007 has had an impact on the development of high-grade lesions associated with HPV16 and HPV18.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Human Papillomavirus Infection | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| biological sample analysis | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Non exposed
- description
- Women born between 1972 and 1982 who were not exposed to HPV vaccination
- interventionNames
- Other: biological sample analysis
- label
- exposed
- description
- Women born between 1983 and 1993 who were potentially exposed to HPV vaccination
- interventionNames
- Other: biological sample analysis
Primary outcomes (1)
- measure
- HPV16 and HPV18 prevalence
- timeFrame
- 18 months
- description
- Prevalence of HPV16 and HPV18 genotypes in high grade cervical lesions of the cervix in women born between 1972 and 1993
Secondary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 27 Years
- Maximum age
- 46 Years
Show eligibility criteria text
Inclusion Criteria: * High grade lesions of the cervix * Histologic diagnosis of cervical intraepithelial neoplasia grade 2 or 3, carinoma in situ * Biopsy or surgical specimen * Formalin-fixed ans paraffin embedded specimen Exclusion Criteria: \- samples fixed in Boin's solution
References
Publications (1)
- DERIVEDLenoir P, Guillet J, Desmarets M, Baraquin A, Ramanah R, Rousse J, Mougin C, Lepiller Q, Pretet JL; HPV Impact Study Group. Human papillomavirus genotype distribution among high-grade cervical lesions in French women born between 1972 and 1993. J Gynecol Obstet Hum Reprod. 2025 May;54(5):102945. doi: 10.1016/j.jogoh.2025.102945. Epub 2025 Mar 21. PMID 40122237