Clinical trial · Interventional
Fluorescence-navigated Thoracoscopy for Detection of Small Pulmonary Nodules
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Fluorescence-navigated thoracoscopic imaging with indocyanine green (ICG) is a novel technique for detection of small pulmonary nodules other than traditional radiography or intraoperative palpation. As a non-targeted fluorescent contrast agent, ICG accumulates in tumors by the enhanced permeability and retention effect (EPR), making the lesions fluoresce under fluorescent imaging. However, the optimal dosage and injection time of ICG are still under exploration. Hence, we perform this study in humans made up of four groups to determine the optimal time and dose.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pulmonary Nodule, Multiple | — | UNRESOLVED | — |
| Pulmonary Nodule, Solitary | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Preoperative Infusion of Indocyanine Green | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- type
- ACTIVE_COMPARATOR
- label
- 5mg/kg of ICG, 24h before surgery
- description
- 5mg/kg of indocyanine green, intravenously injection 24 hours before surgery
- interventionNames
- Procedure: Preoperative Infusion of Indocyanine Green
- type
- EXPERIMENTAL
- label
- 1mg/kg of ICG, 24h before surgery
- description
- 1mg/kg of indocyanine green, intravenously injection 24 hours before surgery
- interventionNames
- Procedure: Preoperative Infusion of Indocyanine Green
- type
- EXPERIMENTAL
- label
- 5mg/kg of ICG, 48h before surgery
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * Peripheral pulmonary solid nodules, with diameter 1-3 cm. * Suitable for surgery and signed informed consent. Exclusion Criteria: * Liver dysfunction. * Allergic to indocyanine green. * Can't tolerate thoracoscopic surgery.
References
Publications (0)
Data not yet available