Study of Endostar Combined With TP Regimen for Esophageal Cancer

Inclusion Criteria:

1. Aged 18 to 75 years;
2. Pathology confirmed as esophageal squamous cell carcinoma and Clinical stage is II-III;
3. Initial treatment, No surgery history;
4. ECOG 0\~2;
5. Expected survival \>=3 months;
6. All the patients should have target lesions that are measurable and evaluable;
7. Should be able to consume liquid diet, no esophageal perforation symptoms, no distant metastases;
8. The main organ function is normal, which meets the following criteria:

(1) The standard of blood test should be met (14 days without blood transfusion and blood products, no G-CSF and other hematopoietic stimulation factor correction): Hb\>=100g/L;ANC\>=1.5x10\^9/L;PLT\>=100x10\^9/L; (2) Biochemical inspection shall meet the following criteria: TBIL \< 1.5 ULN; ALT and AST \< 2.0 ULN.Serum Cr is less than 1.5 ULN or endogenous creatinine clearance rate \> 50 ml/min (the Cockcroft Gault formula); (3) Pulmonary function FEV1 \>=1 L or \>50% of corresponding value of normal people;

9\. Female during the reproductive period should be ensured contraception during the study period; 10. Participants voluntarily joined the study, signed informed consent, and had good compliance and follow-up.

Exclusion Criteria:

1. Patients who do not meet the pathological type of the inclusion criteria and the primary site;
2. Allergic to recombinant endostar, carboplatin, paclitaxel, and contrast agents;
3. Have a distant metastasis;
4. The primary focal tumors or lymph node already had a surgical treatment (except for biopsy), chemoradiotherapy or targeted therapy;
5. Patient who suffered from other malignant tumor;
6. Subject with severe pulmonary and cardiopathic disease history;
7. Pregnant woman or Lactating Women and Women in productive age who refuse take contraception in observation period;
8. Subject with a Personality or psychiatric diseases, people with no legal capacity or people with limited capacity for civil conduct;
9. Received other medicine trials in past 4 weeks;
10. Refuse or incapable to sign the informed consent form of participating this trial;
11. The researchers judged other conditions that could affect clinical research and the results of the study.