Clinical trial · Observational
Single Cell Sequencing Analysis of Thymoma
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to understand how genetics play a role in thymoma. Intratumoral heterogeneity is among the greatest challenges in precision cancer therapy. However, developments in high-throughput single-cell RNA sequencing (scRNA-seq) may now provide the statistical power to dissect the diverse cellular populations of tumors. This study aims to find out how it affects genetic and protein expression in patients with malignant thymoma, compared to Benign thymoma, at a single-cell level using a flow cytometry and RNA-sequencing protocol.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Thymoma | Thymoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Tissue | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Malignant thymoma
- interventionNames
- Diagnostic Test: Tissue
- label
- Benign thymoma
- interventionNames
- Diagnostic Test: Tissue
Primary outcomes (1)
- measure
- Determination of cell population from thymoma
- timeFrame
- through study completion, an average of 1 year
- description
- The genes expression and the cell population
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients diagnosed with thymoma * Ability to provide written consent and comply with the protocol * At least 18 years of age Exclusion Criteria: * Patients undergoing thymoma treatment * Patients with previous malignancy * Known HIV positive status. * Evidence of abnormality of any immune cell population from a drug-induced or genetic cause.
References
Publications (0)
Data not yet available