Clinical trial · Interventional
Elucidation of the Mechanisms and Effects of Certain Anesthetic Interventions on Digestive Cancer Patients Subjected to Surgery
Contributions to the Elucidation of the Mechanisms and Effects by Which Certain Perianesthetic Interventions Modify Long-term Evolution of Patients With Digestive Cancers Subjected to Surgery
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Digestive cancers (liver, colonic, pancreatic) have a high incidence and high mortality, their population prevalence is also increasing. Given that the anesthesia techniques and the agents used act directly and indirectly on the immune system during the perioperative period, influencing both the treatment and the prognosis of patients with colorectal cancer who undergo elective interventions, a series of perianesthetic interventions have been proposed in order to reduce morbidity-mortality perioperative.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Blood extraction | Biological | — | UNRESOLVED |
| Lidocaine 1% Injectable Solution | Drug | — | UNRESOLVED |
| Propofol | Drug | — | UNRESOLVED |
| Sevoflurane | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- type
- EXPERIMENTAL
- label
- Sevoflurane
- description
- Patients will receive a general volatile anesthesia with Sevoflurane as anesthetic agent
- interventionNames
- Biological: Blood extraction
- Drug: Sevoflurane
- type
- EXPERIMENTAL
- label
- Total intravenous anesthesia
- description
- Patients will receive a general anesthesia with Propofol as anesthetic agent
- interventionNames
- Biological: Blood extraction
- Drug: Propofol
- type
- EXPERIMENTAL
- label
- Total intravenous anesthesia and Lidocaine
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * 18 to 80 years old patients admitted for elective colorectal surgery Exclusion Criteria: * Pre-existing chronic pain * Chronic medication that may interfere with pain: antiepileptics, NSAIDs, corticosteroids * Contraindications to any of the medications in the study * Significant psychiatric disorders (Axis I disorder) (major depressive disorders, bipolar disorders, schizophrenia, etc.) * Hepatic (ALT and / or AST\> 2 normal wave) or renal (serum creatinine\> 2 mg / dl) * Convulsive conditions that require medication in the last 2 years * Planned regional analgesia and / or anesthesia (spinal or epidural) * Corticosteroid-dependent asthma * Autoimmune disorders * Antiarrhythmic drugs (verapamil, propafenone, amiodarone) that may interfere with the antiarrhythmic action of lidocaine
References
Publications (0)
Data not yet available