R2 and Combination Chemotherapy Versus R and Combination Chemotherapy in Newly Diagnosed Highly Aggressive B-NHL

Inclusion Criteria:

1. Newly diagnosed highly aggressively B-Cell Non-Hodgkin's lymphoma (NHL) confirmed by histopathology
2. The patient has at least ≥1 measurable tumor lesion with a diameter \>1.5 cm;
3. The patient has not undergone systemic chemotherapy or immunotherapy before;
4. ECOG score ≤ 2 points;
5. Liver and kidney function meets the following conditions: creatinine clearance rate ≥ 30ml / min, total bilirubin, AST and ALT ≤ 2.5 × ULN;
6. No history of malignant tumors within 5 years, except for cured carcinomas in situ such as basal cell carcinoma of the skin, cervical cancer, breast cancer, prostate cancer, etc.;
7. agree to take contraceptive measures during the trial period and within 3 months after the end of the trial;
8. Patients volunteered to participate in the study and signed informed consent.

Exclusion Criteria:

1. Serious cardiovascular and other important organs and blood, endocrine system lesions, and other history of malignant tumors;
2. Severe mental illness;
3. Pregnant or lactating women and men or women who intend to conceive in the near future;
4. The expected survival time is less than 6 months;
5. HBV, HCV or HIV infection or seropositive;
6. there are active infections;
7. Allergies or allergies to rituximab;
8. Compliance or poor follow-up;
9. Other circumstances that the investigator believes are not suitable for inclusion.