Clinical trial · Interventional
An Intraoperative Guidance Platform for Radio Frequency Ablation
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study tests the hypothesis that use of the research RFA (Radiofrequency ablation) Physics Library will result in more frequent technical success (complete necrotization of target tissues) compared to ablations conducted without computer guidance. The RFA Physics Library -- a Planning and Guidance Platform (PGP) (NE Scientific, LLC) -- will be used to support percutaneous liver RFA under CT-guidance by assisting physicians in the identification of ablation targets, assessment of proper ablation probe placement, and projection of the created ablation zones on the CT image.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hepatocellular Carcinoma | Hepatocellular Carcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| RFA Physics Library -- a Planning and Guidance Platform (PGP) | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- RFA Physics Library- PGP
- description
- The RFA Physics Library will be used during during percutaneous liver RFA procedures.
- interventionNames
- Device: RFA Physics Library -- a Planning and Guidance Platform (PGP)
Primary outcomes (2)
- measure
- Rate of Technical Success of Tumor Ablation
- timeFrame
- Success measured at end of RFA procedure, one-time event (lasting up to a few hours)
- description
- Technical success is defined as the complete ablation of the target lesion (tumor and 5 mm margin), as determined by operator.
- measure
- Rate of Local Tumor Recurrence
- timeFrame
- 2 years after RFA treatment
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: 1. ≥ 18 years of age 2. Presence of hepatocellular carcinoma with a size equal or larger than 2cm. 3. Scheduled for CT-guided thermal ablation under General Anesthesia 4. Able to provide written, informed consent Exclusion Criteria: 1. Absolute of relative contraindication to MRI: 1. the presence of an electronic implant, such as a pacemaker not approved for MRI 2. the presence of a metal implant, such as an aneurysm clip not approved for MRI 3. claustrophobia 4. the presence of other contraindication(s), such as inability to comfortably lie flat, history of working with metal, other implanted hardware or shrapnel 2. Target tumor adjacent to or within prior ablated or resected site. 3. Serious psychiatric illness not adequately controlled to permit patient cooperation to obtain an MRI
References
Publications (0)
Data not yet available