Clinical trial · Observational
The Association Between Calretinin and the Function of Ganglion Cells in Hirschsprung Disease
The Association Between Calretinin and the Function of Ganglion Cells in Long Segment and Total Hirschsprung Disease
NCT04149093CI-TRIAL-00050692unknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study aims to compare the outcomes of patients with long segment Hirschsprung disease or total colonic aganglionosis who had negative calretinin staining and positive ganglion cells on the proximal resection margins to those who had both positive findings.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Ganglion | — | UNRESOLVED | — |
| Hirschsprung Disease | — | UNRESOLVED | — |
| Hirschsprung Disease, Long-Segment | — | UNRESOLVED | — |
| Hypoganglionosis | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Calretinin staining | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Long-term outcomes (Quality of life questionnaire)
- timeFrame
- 1 year
- description
- To determine if calretinin has a role in the function of ganglion cells in long segment Hirschsprung disease and total colonic aganglionosis. HAQL (Hirschsprung's disease and Anorectal malformations Quality of Life) questionnaire. For each item the response is scored from 0 to 3 and then, linearly transformed to a 0 (minimum value) to 100 (maximum value) scale. Higher score suggests a better quality of life.
Secondary outcomes (2)
- measure
- Surgical complications
- timeFrame
- 1 year
- description
- * Number of reoperations * Number of rebiopsies * Number of readmissions * Number of bowel obstructions * Number of bowel perforation * Number of anastomotic leaks * Number of anastomotic strictures * Number of fistula * Number of anal stenosis * Number of Hirschsprung-associated enterocolitis
- measure
- Functional outcomes
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 0 Years
- Maximum age
- 18 Months
Show eligibility criteria text
Inclusion Criteria: * Confirmed histopathological diagnosis of Hirschsprung disease from January 1, 1990 to August 31, 2019 * Long-segment Hirschsprung disease (type A and B) * Total colonic aganglionosis (TCA) * Surgery at CHUSJ * Tissue blocks of proximal resection margin available for pathological analysis * Minimum 1 month of postoperative follow-up Exclusion Criteria: * Short-segment Hirschsprung disease (conventional form, rectosigmoid junction) * Total colonic with small bowel aganglionosis (TCSA) * Surgery done at another institution * Early deaths * Lost to follow-up * No documented post-operative outcome
References
Publications (0)
Data not yet available
No reference posted for this study.