Clinical trial · Interventional
Effect of IV Infusion of Lidocaine Compared to IV Infusion of Dexmedetomidine on Proinflammatory Cytokines
Effect of Intravenous Infusion of Lidocaine in Comparison to Intravenous Infusion of Dexmedetomidine on Proinflammatory Cytokines and Stress Response in Pelviabdominal Cancer Surgeries
NCT04148599CI-TRIAL-00046373completedPhase 3ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study is designed to compare between intravenous infusion of dexmedetomidine and intravenous infusion of lidocaine in reduction of proinflammatory cytokines as IL-6 and TNF-α, some stress reactions (serum insulin and serum lactate),and postoperative analgesic requirements in patients undergoing surgery for pelviabdominal cancers.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Inflammatory Response | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| dexmedetomidine infusion | Drug | — | UNRESOLVED |
| lidocaine infusion | Drug | — | UNRESOLVED |
| Placebos | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- ACTIVE_COMPARATOR
- label
- dexmedetomidine
- description
- dexmedetomidine ( precedex) infusion will be administered preoperatively and continued intraoperatively
- interventionNames
- Drug: dexmedetomidine infusion
- type
- ACTIVE_COMPARATOR
- label
- lidocaine
- description
- Lidocaine (Xylocaine) infusion will be administered preoperatively and continued intraoperatively
- interventionNames
- Drug: lidocaine infusion
- type
- PLACEBO_COMPARATOR
- label
- placebo
- description
- saline infusion will be administered preoperatively and continued intraoperatively
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 60 Years
Show eligibility criteria text
Inclusion Criteria: * American society of anesthesia (ASA) Physical Status classification: ASA II physical status. * Age between 18 to 60 years old. * Patients who will undergo major pelviabdominal surgery. Exclusion Criteria: * Patient refusal. * Allergy to local anesthetics. * Cognitive disorders. * uncontrolled diabetes or hypertension.
References
Publications (0)
Data not yet available
No reference posted for this study.