Clinical trial · Interventional
Conventional Endoscopic Mucosal Resection Versus Cold Snare Endoscopic Mucosal Resection of Colonic Lateral Spreading Lesions - A Randomised Controlled Trial
Conventional Versus Cold Snare Endoscopic Mucosal Resection of Colonic Lateral Spreading Lesions - A Randomised Controlled Trial
NCT04138030CI-TRIAL-00087763completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Comparing the complete resection rate and subsequent adenoma recurrence rate at surveillance colonoscopy of 15-40mm laterally spreading adenomas for conventional EMR vs. cold snare EMR.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Adenoma Colon | — | UNRESOLVED | — |
| Colon Adenoma | Colon Adenoma | ONTOLOGY_EXACT | 0.98 |
| Colon Cancer | Malignant Colon Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Cold Snare Endoscopic Mucosal Resection | Procedure | — | UNRESOLVED |
| Conventional Endoscopic Mucosal Resection | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Conventional Endoscopic Mucosal Resection
- description
- Conventional Endoscopic Mucosal Resection (EMR), if necessary, to 15-40mm laterally spreading adenomas.
- interventionNames
- Procedure: Conventional Endoscopic Mucosal Resection
- type
- ACTIVE_COMPARATOR
- label
- Cold Snare Endoscopic Mucosal Resection
- description
- Cold Snare Endoscopic Mucosal Resection (EMR), if necessary, to 15-40mm laterally spreading adenomas.
- interventionNames
- Procedure: Cold Snare Endoscopic Mucosal Resection
Primary outcomes (2)
- measure
- Complete resection rate
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 99 Years
Show eligibility criteria text
Inclusion Criteria: * Any patient undergoing colonoscopy who is older than 18 years of age, has a written consent for trial participation and has at least one LSL meeting to the following description: * Localisation in the colon or rectum * Benign adenomatous surface features (Kudo III / IV, JNET 2a) * Granular or non-granular topography * Paris classification 0-IIa/IIb +/- Is * If present, sessile component may be no greater than 10mm in size. * Polyp size ranging from 15 to 40mm Exclusion Criteria: * Current use of antiplatelet (excluding aspirin) or anticoagulants which have not appropriately been interrupted according to the guidelines. * Known bleeding disorder or coagulopathy. * Pregnancy * History of inflammatory bowel disease * Previously attempted or otherwise non-lifting lesions * Endoscopic features suggestive of submucosal invasion (Kudo Vi/n, JNET 2b / 3) or concurrent CRC * Lesions involving the ileocaecal valve (ICV) or the anorectal junction (ARJ)
References
Publications (1)
- DERIVEDO'Sullivan T, Cronin O, van Hattem WA, Mandarino FV, Gauci JL, Kerrison C, Whitfield A, Gupta S, Lee E, Williams SJ, Burgess N, Bourke MJ. Cold versus hot snare endoscopic mucosal resection for large (>/=15 mm) flat non-pedunculated colorectal polyps: a randomised controlled trial. Gut. 2024 Oct 7;73(11):1823-1830. doi: 10.1136/gutjnl-2024-332807. PMID 38964854