Clinical trial · Observational
Identification of Molecular Biomarkers for Thyroid Cancer
Exploratory Study of the Molecular Profile of Thyroid Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This is a two part study; part A proposes to collect plasma samples to examine how ctDNA (circulating thyroid DNA) markers correlate with detection of recurrent disease, response to therapy, clinical outcome and pathological data. Part B aims to use tissue obtained from biopsies of primary or recurrent disease to establish cell lines and tumour explants to further investigate the biology of thyroid cancer in the preclinical setting
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Thyroid Cancer | Malignant Thyroid Gland Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (2)
- measure
- Primary Objective
- timeFrame
- 3 Years (at the end of study)
- description
- Part A: blood and tumour tissue will be measured to determine molecular profiling.
- measure
- Primary Objective
- timeFrame
- 3 years (at end of study)
- description
- Part B: blood and tumour tissue will be assessed to establish cell lines and to determine patient derived xenograft (PDX) models of thyroid cancer
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * T3-4, N0-1b, M0-M1 thyroid cancer (papillary, follicular, poorly differentiated, anaplastic and medullary thyroid carcinoma). * Patient able to provide informed consent * Patient attending the Royal Marsden Hospital for inpatient or outpatient review * Sufficient tissue sample available to perform analysis (archived or fresh) * Adults \>16 years old Exclusion Criteria: * Patients unable to provide informed consent * Thyroid lymphoma * Metastases to the thyroid * No histological confirmed diagnosis * Only cytology available
References
Publications (0)
Data not yet available