Clinical trial · Observational
What Are the Experiences of Patients With Pseudomyxoma Peritonei?
An Interpretative Phenomenological Analysis of 'Recovery' Following Complete Cytoreductive Surgery.
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): No participants enrolled.
Summary
Brief summary (as posted)
Complete cytoreductive surgery (CCRS) is an extensive, and potentially curative, procedure utilised for peritoneal malignancies including Pseudomyxoma peritonei (PMP). This study aims to provide a nuanced understanding of the lived experience of recovery following CCRS over time, with the view to inform future supportive measures for CCRS patients in particular. This study also provides the opportunity to longitudinally examine patient perceptions of 'recovery' in the context of major illness and/or treatment; i.e. what it is to experience recovery, what is important during recovery, perhaps how this changes over time, and what it is to be 'recovered', if this is possible. A greater understanding of the term may have implications in how it is used, or how patients following major illness are approached by healthcare professionals. Interpretive Phenomenological Analysis (IPA) will be utilised as the guiding methodology in order to answer the study objectives. Potential participants will be approached by the clinical nurse specialist (CNS) involved in the patient's care, and will be offered a 'research study pack', containing a participant information sheet (PIS). A maximum of ten consenting participants will be interviewed on up to six occasions (although only five are planned) across a timeframe of little more than a year, both before and after their surgery. Interviews may take place face-to-face, or via telephone. Data analysis will involve a cyclical process of identifying patterns within the interview transcripts of each participant at each time point, across time points, and between participants. This design will provide an effective means of gathering and analysing rich data from each participant, thus affording a comprehensive insight into the meanings that participants attribute over time to their recovery following CCRS. This study has been devised in partial fulfilment of a doctorate degree at the University of Southampton.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cytoreductive Surgery | — | UNRESOLVED | — |
| Pseudomyxoma Peritonei | Pseudomyxoma Peritonei | ONTOLOGY_EXACT | 0.98 |
| Recovery | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (2)
- measure
- To gather an in-depth understanding of the experiences of patients following complete cytoreductive surgery, using interpretative phenomenological analysis
- timeFrame
- 1 Year
- description
- The primary objective of the study is to elicit an in-depth understanding of the lived experience of 'recovery' in the year following CCRS. Up to ten study participants will be interviewed on up to six occasions, and the data produced will be analysed using interpretative phenomenological analysis.
- measure
- To gather an in-depth understanding of the meaning of recovery to patients after complete cytoreductive surgery, using interpretative phenomenological analysis
- timeFrame
- 1 Year
- description
- The secondary objective of the study is to identify the meaning(s) of 'recovery' to study participants over time in the year following CCRS. Up to ten study participants will be interviewed on up to six occasions, and the data produced will be analysed using interpretative phenomenological analysis.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 16 Years
Show eligibility criteria text
Inclusion Criteria: Patients are eligible to be invited to participate in the study if… 1. They are electively booked in… 2. … for Complete Cytoreducive Surgery (CCRS)… 3. … for 'four-quadrant' Pseudomyxoma peritonei (PMP)… 4. … at Basingstoke and North Hampshire Hospital (BNHH). 5. They are 16 years old or over. 6. They live within an approximate 100 mile radius of BNHH. 7. They are able to converse in English, without the assistance of others. 8. They are deemed able to independently make an informed decision whether or not to participate in the study (i.e. the individual must appear able to understand, retain and use or weigh up information as part of decision making processes) Exclusion Criteria: 1. Potential participants are excluded if they have had a previous diagnosis of cancer. 2. Potential participants are also excluded if they have had, or are due to have, a treatment of systemic chemotherapy.
References
Publications (10)
- BACKGROUNDGlehen O, Kwiatkowski F, Sugarbaker PH, Elias D, Levine EA, De Simone M, Barone R, Yonemura Y, Cavaliere F, Quenet F, Gutman M, Tentes AA, Lorimier G, Bernard JL, Bereder JM, Porcheron J, Gomez-Portilla A, Shen P, Deraco M, Rat P. Cytoreductive surgery combined with perioperative intraperitoneal chemotherapy for the management of peritoneal carcinomatosis from colorectal cancer: a multi-institutional study. J Clin Oncol. 2004 Aug 15;22(16):3284-92. doi: 10.1200/JCO.2004.10.012. PMID 15310771
- BACKGROUNDSugarbaker PH. Peritonectomy procedures. Ann Surg. 1995 Jan;221(1):29-42. doi: 10.1097/00000658-199501000-00004. PMID 7826158
- BACKGROUNDChua TC, Yan TD, Saxena A, Morris DL. Should the treatment of peritoneal carcinomatosis by cytoreductive surgery and hyperthermic intraperitoneal chemotherapy still be regarded as a highly morbid procedure?: a systematic review of morbidity and mortality. Ann Surg. 2009 Jun;249(6):900-7. doi: 10.1097/SLA.0b013e3181a45d86. PMID 19474692
- BACKGROUNDDube P, Sideris L, Law C, Mack L, Haase E, Giacomantonio C, Govindarajan A, Krzyzanowska MK, Major P, McConnell Y, Temple W, Younan R, McCart JA. Guidelines on the use of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in patients with peritoneal surface malignancy arising from colorectal or appendiceal neoplasms. Curr Oncol. 2015 Apr;22(2):e100-12. doi: 10.3747/co.22.2058. PMID 25908915
- BACKGROUNDShan LL, Saxena A, Shan BL, Morris DL. Quality of life after cytoreductive surgery and hyperthermic intra-peritoneal chemotherapy for peritoneal carcinomatosis: A systematic review and meta-analysis. Surg Oncol. 2014 Dec;23(4):199-210. doi: 10.1016/j.suronc.2014.10.002. Epub 2014 Oct 28. PMID 25466850
- BACKGROUNDStearns AT, Malcomson L, Punnett G, Abudeeb H, Aziz O, Selvasekar CR, Fulford PE, Wilson MS, Renehan AG, O'Dwyer ST. Long-term Quality of Life After Cytoreductive Surgery and Heated Intraperitoneal Chemotherapy for Pseudomyxoma Peritonei: A Prospective Longitudinal Study. Ann Surg Oncol. 2018 Apr;25(4):965-973. doi: 10.1245/s10434-017-6326-0. Epub 2018 Jan 8.