Clinical trial · Interventional
DNA Repair Activity in the Skin of Day and Night Shift Workers
Pilot Study on DNA Repair Activity in the Skin of Day and Night Shift Workers
NCT04122456CI-TRIAL-00118519recruitingN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to test how the skin of night shift workers responds to artificial sunlight (ultraviolet B radiation; UVB) at two different times of the day in comparison to normal day shift workers. After the skin biopsies are obtained, they will be brought to the laboratory to be exposed to UVB radiation and to measure UVB responses.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Skin Cancer | Malignant Skin Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| No Ultraviolet B Radiation | Other | — | UNRESOLVED |
| Ultraviolet B Radiation | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Day Shift Work Schedule
- description
- Day shift worker skin biopsies will be exposed to artificial sunlight (ultraviolet B radiation; UVB) at the laboratory.
- interventionNames
- Radiation: Ultraviolet B Radiation
- Other: No Ultraviolet B Radiation
- type
- EXPERIMENTAL
- label
- Night Shift Work Schedule
- description
- Night shift worker skin biopsies will be exposed to artificial sunlight (ultraviolet B radiation; UVB) at the laboratory.
- interventionNames
- Radiation: Ultraviolet B Radiation
- Other: No Ultraviolet B Radiation
Primary outcomes (4)
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 40 Years
Show eligibility criteria text
Inclusion Criteria: * Male/Female * Fair skin (Fitzpatrick types I and II) * Age 18 to 40 * Able to comprehend procedures/risks * Primarily work and are awake during normal daylight hours (6 am to 6 pm), or primarily work and are awake during night shifts hours (between the hours of 6 pm and 6 am) or may work a mixture of these shifts over the past 3 months. Rotating shifts will be categorized based on the majority of hours worked on average during the last 3 months. Able to fill out a 3-month calendar of work schedule. Exclusion Criteria: * Known photosensitivity * Currently on photosensitizing medications * Diabetes Mellitus * On any hormonal agents (e.g., birth control pills) * History of abnormal scarring * History of skin infections * History of skin cancers * History of sleep disorders such as sleep apnea or insomnia * Known allergy to lidocaine local anesthetic * Pregnancy or nursing * Other serious health issues
References
Publications (0)
Data not yet available
No reference posted for this study.