Clinical trial · Interventional
Cordotomy in Reducing Pain in Patients With Advanced Cancer
Percutaneous Cordotomy for Pain Palliation in Advanced Cancer
NCT04119037CI-TRIAL-00105210active not recruitingN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 17, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260917-000001
Summary
Brief summary (as posted)
This trial studies how well cordotomy works in reducing pain in patients with cancer that has spread to other places in the body (advanced). Cordotomy is performed on the spinal cord with a needle and guided by computed tomography scans and is designed to help reduce pain. This study is being done to learn if a cordotomy reduces pain in patients with unmanageable cancer pain.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Advanced Malignant Neoplasm | Malignant Neoplasm | CURATED_BROADER | 0.78 |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Cordotomy | Procedure | — | UNRESOLVED |
| Morphine | Drug | — | UNRESOLVED |
| Questionnaire Administration | Other | — | UNRESOLVED |
| Sham Intervention | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Group I (cordotomy)
- description
- Patients undergo a cordotomy over 1-2 hours.
- interventionNames
- Procedure: Cordotomy
- Other: Questionnaire Administration
- type
- SHAM_COMPARATOR
- label
- Group II (morphine, fake cordotomy)
- description
- Patients receive morphine via injection into the spine and undergo a fake cordotomy over 1-2 hours.
- interventionNames
- Drug: Morphine
- Other: Questionnaire Administration
- Procedure: Sham Intervention
Primary outcomes (1)
- measure
- Reduction in pain intensity
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Ability to provide informed consent * Has undergone 3 palliative care evaluations * Pain intensity \>= 4 on a 0-10 numerical scale * Unilateral pain due to cancer below the shoulder level (arm, trunk, hip, leg) Exclusion Criteria: * Uncorrectable coagulopathy * Large intracranial mass * Inability to complete assessment forms * Life expectancy \< 1 month * Contraindication to intravenous sedation * Morphine allergy
References
Publications (0)
Data not yet available
No reference posted for this study.